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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Research Article

In Vitro α-glucosidase Inhibition and Computational Studies of Kaempferol Derivatives from Dryopteris cycanida

Author(s): Surriya Amin, Barkat Ullah, Mumtaz Ali*, Haroon Khan*, Abdur Rauf, Sher A. Khan and Eduardo Sobarzo-Sánchez*

Volume 20, Issue 9, 2020

Page: [731 - 737] Pages: 7

DOI: 10.2174/1568026620666200130161033

Price: $65

Abstract

Background: Dryopteris cycadina has diverse traditional uses in the treatment of various human disorders which are supported by pharmacological studies. Similarly, the phytochemical studies of this plant led to the isolation of numerous compounds.

Methodology: The present study deals with α-glucosidase inhibition of various kaempferol derivates including kaempferol-3, 4/-di-O-α- L-rhamnopyranoside 1, kaempferol-3, 5-di-O-α-L-rhamnoside 2 and kaempferol-3,7-di-O-α- L-rhamnopyranoside 3.

Results: The results showed marked concentration-dependent inhibition of the enzyme when assayed at different concentrations and the IC50 values of compounds 1-3 were 137±9.01, 110±7.33, and 136±1.10 mM, respectively far better than standard compound, acarbose 290±0.54 mM. The computational studies revealed strong docking scores of these compounds and augmented the in vitro assay.

Conclusion: In conclusion, the isolated kaempferol derivatives 1-3 from D. cycadina exhibited potent α- glucosidase inhibition.

Keywords: Dryopteris cycadina, Kaempferol derivatives, α-glucosidase inhibition, Molecular docking studies, Isolated kaempferol derivatives, epithelial cells.

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