The side-chains of quinoline antimalarial agents are the major concern of focus to build
novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a
critical role in pH trapping in the food vacuole of RBC’s with the help of fragmented amino acid, thus
lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation
of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc.
of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.
Keywords: Chloroquine, P. falciparum, Antiplasmodial activity, β-HI activity, Cytotoxicity, Quinoline.
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