Prognostic Role of Hedgehog GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers

(E-pub Ahead of Print)

Author(s): Prasuja Rokkam, Shailender Gugalavath, Deepak KGK, Rahul Kumar Vempati, Rama Rao Malla*.

Journal Name: Current Drug Metabolism


Abstract:

Glioma-associated oncogene homolog 1 (GLI1) is reported as an amplified gene in human glioblastoma cells. It is a krupple like transcription factor, belonging to the zinc finger family. The basic function of GLI1 is normal neural development in various stages of human. The GLI1 gene was first mapped on the chromosome sub-bands 12q13.3-14.1. Further, single nucleotide polymorphism is mostly observed in translating a region of 5’ and 3’- UTR of GLI1 gene in addition to two post-transcriptional splice variants, GLI∆N and tGLI. Additionally, it also regulates a plethora of gene which mediates crucial cellular processes like proliferation, differentiation, oncogenesis, EMT, and metastasis. It also regulates tumor tolerance, chemoresistance, and radioresistance. Aberrant expression of GLI1 predicts the poor survival of breast cancer patients. GLI1 is an essential mediator of the SHH signalling pathway regulating self-renewal of stem cells, angiogenesis, and expression of FOXS1, CYR61. GLI1 mediated HH pathway can induce apoptosis. These GLI1 can be a future diagnostic, prognostic marker and as well as a potent target of therapeutics in breast cancer.

Keywords: Breast cancer, Carcinogenesis, EMT, GLI1, HH signalling pathway, Resistance

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389200221666200122120625
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