Green Three-Component Synthesis of Merocyanin Dyes Based on 4- Arylideneisoxazol-5(4H)-ones

(E-pub Ahead of Print)

Author(s): Fatemeh Khorsi Damghani, Hamzeh Kiyani*, Seied Ali Pourmousavi.

Journal Name: Current Green Chemistry

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A one-pot three-component reaction promoted by choline chloride: zinc(II) chloride deep-eutectic solvent (ChCl-ZnCl2 DES) in an aqueous medium for the synthesis of several merocyanin dyes based on isoxazol-5(4H)-ones are presented. This three-component approach is efficient, clean, experimentally simple, convenient, safe, and environmentally friendly. This reaction was performed at room temperature without using energy sources such as, heat, microwave, and ultrasound waves. Non-use of toxic solvents, available materials, one-vessel, no wasted reagents, simple preparation, and recyclability of DES are other important points of this method that is significant from the perspective of green chemistry.

Keywords: Choline chloride, Deep-eutectic solvent, Green synthesis, Isoxazol-5(4H)-ones, Three-component reaction, Zinc(II) chloride

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(E-pub Ahead of Print)
DOI: 10.2174/2213346107666200122093906