Background: Genistein being a phytoestrogen imitates the characteristics of estrogen, which can be useful
to treat conditions by reducing the estrogen levels at the time of menopause, osteoporosis and high risk for breast
Objective: The superior binding of genistein to ERβ might help in reducing breast malignancy risk.
Conclusion: Genistein induces cell cycle arrest, anti-metastatic properties and ultimately affects the breast cancer
cell growth by multiple mechanisms. Genistein-mediated anti-proliferative or anti-growth effects are usually observed
at higher concentrations. These signaling pathways involve the decrease of NF-κB, HIF-1α, VEGF, and an
increase of tumor suppressor p21. This will provide further insight into understanding the biology of transcription
factors NF-κB, and HIF-1α in breast cancer.