Current Nanoparticles Approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review

(E-pub Ahead of Print)

Author(s): Mohammad Azam Ansari, Ill-Min Chung, Govindasamy Rajakumar, Mohammad A. Alzohairy, Mohammad N. Alomary, Muthu Thiruvengadam*, Faheem Hyder Pottoo, Niyaz Ahmad.

Journal Name: Current Pharmaceutical Design


Abstract:

Nanoparticles (NPs) are unique may be organic, or inorganic, play a vital role in the development of drug delivery targeting the brain and central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy and attractive application for drug delivery to the brain and CNS disorders and related diseases such as Parkinson's disease, Alzhemier's disease and brain solid tumors. Blood brain barrier (BBB) and blood cerebrospinal fluid barriers are natural protective hindrances to enter any drug molecules into the CNS and brain. Nanoparticles exhibit excellent intruding capacity for therapeutic agents and overcome the risk of protective barriers. By using nanotechnology based NPs targeting drug delivery can be improved across BBB and to discharge drugs in a controlled manner. NPs confer safe from degradation phenomenon. Several kinds of NPs are used for nose to brain (N2B) enroute such as lipidemic nanoparticles, polymeric nanoparticles, inorganic NPs, solid lipid NPs, dendrimers. Among them, popular lipidemic and polymeric NPs are discussed, and their participation in anti-cancer activity have also been highlighted in this review.

Keywords: Nanoparticles, polymeric, anticancer, nose to brain drug delivery

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1381612826666200116153912
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