L-glutaminase has versatile applications in pharma and food industries. In pharmaceutical industry,
L-glutaminase can be used as anti-oxidant and anti-cancer agent to treat Acute Lymphocytic Leukaemia (ALL).
Whereas, in the food industry, L-glutaminase is used for acrylamide degradation, theanine production, flavour enhancer,
soy sauce and many. The other applications include nitrogen metabolism and its use as biosensor in hybridoma
technology. Both intra-cellular and extra-cellular L-glutaminases from wide range of sources were identified.
Because of its diverse applications, there is a need to improve the production of L-glutaminase by enzyme engineering
technology. Effect of recombination on L-glutaminase production was also reported. Researchers also confirmed
the antitumor properties of L-glutaminase by conducting in vitro, in vivo and in silico studies. Bacillus sps. and Aspergillus
sps. are the commercial producers of L-glutaminase. In this review, the applications, different sources of Lglutaminase,
anti-cancer properties were discussed.
Keywords: Acute lymphocytic leukaemia (ALL), L-glutaminase, therapeutic enzyme, production, optimization, enzyme engineering, food
industry, pharma industry, biosensor, acrylamide, in vitro, in vivo, in silico studies.
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