Versatile and Valuable Utilization of Amidohydrolase L-Glutaminase in Pharma and Food industries: A Review

(E-pub Ahead of Print)

Author(s): Chandrasai Potla Durthi*, Madhuri Pola, Satish Babu Rajulapati*, Anand Kishor Kola, Mohammad Amjad Kamal.

Journal Name: Current Drug Metabolism


Abstract:

L-Glutaminase has versatile applications in Pharma and food industries. In the pharmaceutical industry, LGlutaminase can be used as anti-oxidant and anti-cancer agent to treat Acute Lymphocytic Leukaemia (ALL). Whereas, in the food industry, L-Glutaminase is used for acrylamide degradation, theanine production, flavour enhancer, soy sauce and many. The other applications include nitrogen metabolism and its use as biosensor in hybridoma technology. Both intra-cellular and extra-cellular L-Glutaminases from wide range of sources were identified. Because of its diverse applications, there is a need to improve the production of L-Glutaminase by enzyme engineering technology. Effect of recombination of L-Glutaminase production was also reported. Researchers also confirmed the antitumor properties of L-Glutaminase by conducting in vitro, in vivo and in silico studies. Bacillus sps. and Aspergillus sps. are the commercial producers of L-Glutaminase. In this review, the applications, different sources of L-Glutaminase, anti-cancer properties were discussed.

Keywords: Acute Lymphocytic Leukaemia (ALL), L-Glutaminase, Therapeutic enzyme, Production, Optimization, Enzyme Engineering, Food industry, Pharma Industry, Biosensor, Acrylamide, In vitro, In vivo, In silico studies

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1574884715666200116110542
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