Exploring Dysregulated Signaling Pathways in Cancer

(E-pub Ahead of Print)

Author(s): Sabah Nisar, Sheema Hashem, Muzafar A. Macha, Santosh K. Yadav, Sankavi Muralitharan, Lubna Azeez, Geetanjali Sageena, Hamda Al-Naemi, Mohammad Haris, Ajaz A. Bhat*.

Journal Name: Current Pharmaceutical Design


Abstract:

Cancer cell biology takes the advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from exterior of cell to intracellular mediators, as well as intracellular interactions that governs diverse cellular processes. Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to improvement of targeted tumor therapy. In this review article, we discussed different signaling pathways and how their dysregulation contributes to the development of tumors.

Keywords: angiogenesis, apoptosis, cell invasion, cell proliferation, drug targets, metastasis, signaling pathways, tumor microenvironment

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1381612826666200115095937
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