Emerging Role of Angiotensin AT2 Receptor in Anti-Inflammation: An Update

(E-pub Ahead of Print)

Author(s): Sanket N. Patel, Naureen Fatima, Riyasat Ali, Tahir Hussain*.

Journal Name: Current Pharmaceutical Design


Abstract:

The hyperactive RAS and inflammation are closely associated. The angiotensin-II/AT1R axis of the RAS has been explored extensively for its role in inflammation and a plethora of pathological conditions. Understanding the role of AT2R in inflammation is an emerging area of research. The AT2R is expressed on a variety of immune and non-immune cells, which upon activation triggers the release of a host of cytokines and has multiple effects that coalesce to anti-inflammation and prevents maladaptive repair. The anti-inflammatory outcomes of AT2R activation are linked to its well-established signaling pathways involving formation of nitric oxide and activation of phosphatases. Collectively, these effects promote cell survival and tissue function. For the consideration of AT2R as a therapeutic target requires further investigations.

Keywords: angiotensin-II type 2 receptor, inflammation, nitric oxide

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1381612826666200115092015
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