Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease

(E-pub Ahead of Print)

Author(s): Zhao Yuan, Zhang Yidan, Zhang Jian, Zhang Xiangjian, Yang Guofeng*.

Journal Name: Current Neuropharmacology

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Abstract:

Alzheimer’s disease (AD) is a neurodegenerative disorder of progressive dementia that is characterized by the accumulation of beta-amyloid (Aβ)-containing neuritic plaques and intracellular Tau protein tangles. This distinctive pathology indicates that the protein quality control is compromised in AD. Autophagy functions as a “neuronal housekeeper” that eliminates aberrant protein aggregates by wrapping then into autophagosomes and delivering them to lysosomes for degradation. Several studies have suggested that autophagy deficits participate in the accumulation and propagation of misfolded proteins (including Aβ and Tau). In this review, we summarize current knowledge of autophagy in the pathogenesis of AD, as well as some pathways targeting the restoration of autophagy. Moreover, we discuss how these aspects can contribute to the development of disease-modifying therapies in AD.

Keywords: Alzheimer's disease; Autophagy; Amyloid beta; Tau; Propagation of amyloid beta and Tau; mTOR-dependent pathway; mTOR-independent pathway; Autophagy-related interventions

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570159X18666200114163636
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