A Comprehensive Review: Bio-Potential of Barbituric Acid and its Analogues

Author(s): Nusrat Shafiq*, Uzma Arshad, Gul Zarren, Shagufta Parveen, Irum Javed, Aisha Ashraf.

Journal Name: Current Organic Chemistry

Volume 24 , Issue 2 , 2020

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In our present work, we emphasized on the potential of barbituric acid (1) derivatives as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal agents. As naturally occurring, barbituric acid (1) is inactive but in the derivative form, it has a large number of medicinal uses and nowadays, it has a great demand in the pharmaceutical industry. Barbituric acid has a wide range of applications in the synthesis of a diverse class of compounds like heterocyclic, carbocyclic, synthetic alkaloids, and due to its broad-spectrum applications, barbituric acid acquired the position of building blocks in synthetic chemistry. Through the history of humanity, a number of bioactive agents have been applied to cure the disease related to hypnotics and sedatives, while the exact efficacy of these agents was found to be limited. Till now, review articles on barbituric acid only express their specific aspect but in present review article, all aspects are discussed in detail to provide a platform to readers and researchers so that they could obtain all information and background knowledge from a single point.

Keywords: Anti-microbial, Anti-fungal, Barbituric acid derivatives, Hypnotic, Luminal, Multi-component reactions, Phenobarbital Sedative.

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Article Details

Year: 2020
Page: [145 - 177]
Pages: 33
DOI: 10.2174/1385272824666200110094457
Price: $95

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