A COMPREHENSIVE REVIEW: BIO-POTENTIAL OF BARBITURIC ACID AND ITS ANALOGUES

(E-pub Abstract Ahead of Print)

Author(s): Nusrat Shafiq*, Uzma Arshad, Gul Zarren, Shagufta Parveen, Irum Javed, Aisha Ashraf.

Journal Name: Current Organic Chemistry

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Abstract:

In our present work, we emphasized on potential of barbituric acid (1) derivatives as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal agents. As naturally occurring barbituric acid (1) is inactive but in derivative form, it has a large number of medicinal uses and now a day, it has a great demand in pharmaceutical industry. Barbituric acid has wide range of applications in synthesis of diverse class of compounds like heterocyclic, carbocyclic, synthetic alkaloids and due to its broad-spectrum applications barbituric acid acquired position of building blocks in synthetic chemistry. All the way through the history of humanity, number of bioactive agents has been applied to cure the disease related to hypnotics and sedatives while the exact efficacy of these agents was found to be limited. Till now review articles on barbituric acid only express their specific aspect but in present review article all aspects were discussed in detail to provide a plate form to readers and researchers so that they could obtain all information and background knowledge from a single point.

Keywords: Anti-Microbial, Anti-Fungal, Barbituric Acid Derivatives, Hypnotic, Luminal, Multi-Component Reactions, Phenobarbital Sedative

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1385272824666200110094457
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