Emerging Role of Mitophagy in Inflammatory Diseases: Cellular and Molecular Episodes

(E-pub Ahead of Print)

Author(s): Mohamed Adil, Shabnam Ameenudeen, Ashok Kumar, S Hemalatha, Neesar Ahmed, Nemat Ali, Abdullah F. AlAsmari, Mohammad Aashique, Mohammad Waseem*.

Journal Name: Current Pharmaceutical Design


Abstract:

Mitochondria are the crucial regulators for major source of ATP for different cellular events. Due to damage episodes, mitochondria have been established for plethora of an alarming signals of stress that leads to cellular deterioration and thereby causing programmed cell death. Defects in mitochondria plays a key role in arbitrating pathophysiological machinery with recent evince delineating a constructive role in mitophagy mediated mitochondrial injury. Mitophagy have been known for eradication of damaged mitochondria via autophagy process. Mitophagy has been investigated as an evolutionarily conserved mechanism for mitochondrial quality control and homeostasis. Impaired mitophagy has been critically linked with pathogenesis of inflammatory diseases. Nevertheless, the exact mechanism is not quite revealed, and it is still debatable. The purpose of this review was to enquire the possible role of mitophagy and its associated mechanism in inflammation mediated diseases at both cellular and molecular level.

Keywords: Mitochondria, Mitophagy, Oxidative Stress, Inflammation, Energy Homeostasis, Inflammasomes

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1381612826666200107144810
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