The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

Author(s): Sun-Wung Hsieh, Ming-Wei Liu, Ling-Chun Huang, Meng-Ni Wu, Yuan-Han Yang*.

Journal Name: Current Alzheimer Research

Volume 16 , Issue 14 , 2019

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Abstract:

Background: The Angiotensin-Converting Enzyme (ACE) gene has drawn attention for its possible role in regulating the degradation of β-amyloid (Aβ), yet its role in affecting the cognitive and psychiatric symptoms of Alzheimer`s Disease (AD) patients has yet to be elucidated.

Objective: This study aimed to investigate whether the ACE gene acts as a risk factor of Behavioral and Psychological Symptoms of Dementia (BPSD) in the AD population.

Methods: The genotyping of ACE and Apolipoprotein E gene with allele ε4(APOEε4) was determined among 360s clinically diagnosed AD patients. Symptoms and severity of BPSD were evaluated annually via Neuropsychiatric Inventory (NPI).

Results: At the base measurement of the first year of patient recruitment, there were no significant contributory risk factors to NPI score. In the two-year follow-up, ACE insertion polymorphism showed a significant risk (adjusted odds ratio=1.65, 95% CI=1.1- 2.5, p=0.019) of progression of NPI total score.

Conclusion: ACE gene is involved in aggravating BPSD among AD patients.

Keywords: Alzheimer's disease, angiotensin-converting enzyme gene, apolipoprotein E gene, behavioral and psychological symptoms of dementia, neuropsychiatric inventory, β-amyloid.

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VOLUME: 16
ISSUE: 14
Year: 2019
Page: [1269 - 1275]
Pages: 7
DOI: 10.2174/1567205017666200103114550
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