Network Pharmacology Analysis on Zhichan Powder in the Treatment of Parkinson's Disease

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Author(s): Jia Li, Xinchang Qi, Yajuan Sun, Yingyu Zhang, Jiajun Chen*.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

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Purpose: Effective components and mechanism of action of Zhichan Powder in treatment of Parkinson's disease were researched at a systematic level.

Method: With methods in computer network pharmacology, screening of active components in Zhichan Powder for treatment of Parkinson's disease in the database of Traditional Chinese Medicine Systems Pharmacology was conducted, and a medicine-target-disease network was established.

Results: With methods in network pharmacology, we selected 18 major active components in Zhichan Powder through screening, indicating a certain connection between chemical components in this traditional Chinese medicine and its targets and Parkinson's disease.

Conclusion: The system of Zhichan Powder established based on network pharmacology can realize visualization of clustering and differences among chemical components in this prescription as well as the complex mechanism of molecular action among those effective components, relevant targets, pathways and the disease and thus provides a new perspective and method for revealing mechanism of action of traditional Chinese medicine prescriptions.

Keywords: Parkinson's disease, Network pharmacology, Traditional Chinese Medicine, Zhichan Powder

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1386207323666200102124302
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