Organocatalytic Combinatorial Synthesis of Quinazoline, Quinoxaline and Bis(indolyl)methanes

(E-pub Abstract Ahead of Print)

Author(s): Fatemeh Malamiri, Samad Khaksar*, Rashid Badri, Elham Tahanpesar.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

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Aim and Objective: An efficient and practical procedure for the synthesis of heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was developed using 3,5-bis(trifluoromethyl) phenylammonium hexafluorophosphate(BFPHP) as a novel organocatalyst.

Material and method: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR and melting points.

Results: Various product were obtained in good to excellent yields under reaction conditions.

Conclusion: The BFPHP organocatalyst demonstrates a novel class of non-asymmetric organocatalyst, which are gaining much attention in green chemistry.

Keywords: Organocatalyst, Green Chemistry, Quinazoline, Multicomponent, Heterocyclic, Anticancer

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1386207323666191213123026
Price: $95