The nasal septal cartilage plays an important role in the growth of midface and as a vertical
strut preventing the collapse of the nasal bones. The repair of nasal cartilage defects remains a major
challenge in reconstructive surgery. The tissue engineering strategy in the development of tissue has
opened a new perspective to generate functional tissue for transplantation. Given the poor regenerative
properties of cartilage and a limited amount of autologous cartilage availability, intense interest has
evoked for tissue engineering approaches for cartilage development to provide better outcomes for
patients who require nasal septal reconstruction. Despite numerous attempts to substitute the shapely
hyaline cartilage in the nasal cartilages, many significant challenges remained unanswered. The aim of
this research was to carry out a critical review of the literature on research work carried out on the
development of septal cartilage using a tissue engineering approach, concerning different cell sources,
scaffolds and growth factors, as well as its clinical pathway and trials have already been carried out.
Keywords: Cartilage, nasal septal, graphene, tissue engineering, stem cells, cartilage.
Nezakati T, Seifalian A, Tan A, Seifalian AM. Conductive Polymers: Opportunities and Challenges in Biomedical Applications Chem Rev 2018; 25;118(14): 6766-843.
Seifalian A, Hancock S. Composite material and its method of production Patent number: GB 2569670 2019.
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