Login Register Cart 0
Generic placeholder image

Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Applicability of Low-intensity Vibrations as a Regulatory Factor on Stem and Progenitor Cell Populations

Author(s): Oznur Baskan, Ozge Karadas, Gulistan Mese and Engin Ozcivici*

Volume 15, Issue 5, 2020

Page: [391 - 399] Pages: 9

DOI: 10.2174/1574888X14666191212155647

Price: $65

Abstract

Persistent and transient mechanical loads can act as biological signals on all levels of an organism. It is therefore not surprising that most cell types can sense and respond to mechanical loads, similar to their interaction with biochemical and electrical signals. The presence or absence of mechanical forces can be an important determinant of form, function and health of many tissue types. Along with naturally occurring mechanical loads, it is possible to manipulate and apply external physical loads on tissues in biomedical sciences, either for prevention or treatment of catabolism related to many factors, including aging, paralysis, sedentary lifestyles and spaceflight. Mechanical loads consist of many components in their applied signal form such as magnitude, frequency, duration and intervals. Even though high magnitude mechanical loads with low frequencies (e.g. running or weight lifting) induce anabolism in musculoskeletal tissues, their applicability as anabolic agents is limited because of the required compliance and physical health of the target population. On the other hand, it is possible to use low magnitude and high frequency (e.g. in a vibratory form) mechanical loads for anabolism as well. Cells, including stem cells of the musculoskeletal tissue, are sensitive to high frequency, lowintensity mechanical signals. This sensitivity can be utilized not only for the targeted treatment of tissues, but also for stem cell expansion, differentiation and biomaterial interaction in tissue engineering applications. In this review, we reported recent advances in the application of low-intensity vibrations on stem and progenitor cell populations. Modulation of cellular behavior with low-intensity vibrations as an alternative or complementary factor to biochemical and scaffold induced signals may represent an increase of capabilities in studies related to tissue engineering.

Keywords: Stem cell, vibrations, biomechanics, mechanobiology, tissue engineering, progenitor cell populations.

« Previous Next »
[1]
Wong M, Siegrist M, Cao X. Cyclic compression of articular cartilage explants is associat-ed with progressive consolidation and altered expression pat-tern of extracellular matrix proteins, Matrix biology journal of the International Society for Matrix Biology 1999;; 18(4): 391-9..
[2]
Đorđević S, Tomažič S, Narici M, Pišot R, Meglič A. In-vivo measurement of muscle tension: dynamic properties of the MC sensor during isometric muscle contraction. Sensors (Basel) 2014; 14(9): 17848-63.
[http://dx.doi.org/10.3390/s140917848] [PMID: 25256114]
[3]
Barnes GRG, Pinder DN. In vivo tendon tension and bone strain measurement and correlation. J Biomech 1974; 7(1): 35-42.
[http://dx.doi.org/10.1016/0021-9290(74)90068-2] [PMID: 4820650]
[4]
Manley PA, Schatzker J, Sumner-Smith G. Evaluation of tension and compression forces in the canine femur in vivo. Arch Orthop Trauma Surg 1982; 99(3): 213-6.
[http://dx.doi.org/10.1007/BF00379211] [PMID: 7073450]
[5]
Ozcivici E, Judex S. Trabecular bone recovers from mechanical unloading primarily by restoring its mechanical function rather than its morphology. Bone 2014; 67: 122-9.
[http://dx.doi.org/10.1016/j.bone.2014.05.009] [PMID: 24857858]
[6]
Reneman RS, Hoeks APG. Wall shear stress as measured in vivo: consequences for the design of the arterial system. Med Biol Eng Comput 2008; 46(5): 499-507.
[http://dx.doi.org/10.1007/s11517-008-0330-2] [PMID: 18324431]
[7]
Yap CH, Saikrishnan N, Tamilselvan G, Yoganathan AP. Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet. Biomech Model Mechanobiol 2012; 11(1-2): 171-82.
[http://dx.doi.org/10.1007/s10237-011-0301-7] [PMID: 21416247]
[8]
Gooch KJ, Tennant CJ. Mechanical Forces: Their Effects on Cells and Tissues. Springer 1997.
[http://dx.doi.org/10.1007/978-3-662-03420-0]
[9]
Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 1985; 37(4): 411-7.
[http://dx.doi.org/10.1007/BF02553711] [PMID: 3930039]
[10]
Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS. Gross, Low-magnitude mechanical loading becomes osteo-genic when rest is inserted between each load cycle, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002; 17(9): 1613-20..
[11]
Hsieh YF, Turner CH. Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 2001; 16(5): 918-24.
[http://dx.doi.org/10.1359/jbmr.2001.16.5.918] [PMID: 11341337]
[12]
Beck BR, Kent K, Holloway L, Marcus R. Novel, high-frequency, low-strain mechanical loading for premenopausal women with low bone mass: early findings. J Bone Miner Metab 2006; 24(6): 505-7.
[http://dx.doi.org/10.1007/s00774-006-0717-9] [PMID: 17072744]
[13]
Ozcivici E, Kim Luu Y, Adler B, et al. Mechanical signals as anabolic agent in bone 2010.
[http://dx.doi.org/10.1038/nrrheum.2009.239]
[14]
Luu YK, Ozcivici E, Capilla E, et al. Development of diet-induced fatty liver disease in the aging mouse is suppressed by brief daily exposure to low-magnitude mechanical signals. Int J Obes 2010; 34(2): 401-5.
[http://dx.doi.org/10.1038/ijo.2009.240] [PMID: 19935747]
[15]
Judex S, Lei X, Han D, Rubin C. Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude. J Biomech 2007; 40(6): 1333-9.
[http://dx.doi.org/10.1016/j.jbiomech.2006.05.014] [PMID: 16814792]
[16]
Judex S, Koh TJ, Xie L. Modulation of bone’s sensitivity to low-intensity vibrations by acceleration magnitude, vibration duration, and number of bouts. Osteoporos Int 2015; 26(4): 1417-28.
[http://dx.doi.org/10.1007/s00198-014-3018-5] [PMID: 25614140]
[17]
Gröning F, Fagan M, O’higgins P. Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study. Anat Rec (Hoboken) 2013; 296(1): 9-18.
[http://dx.doi.org/10.1002/ar.22597] [PMID: 22976999]
[18]
Li Y, Li Y, Zhang Q, et al. Mechanical Properties of Chondrocytes Estimated from Different Models of Micropipette Aspiration. Biophys J 2019; 116(11): 2181-94.
[http://dx.doi.org/10.1016/j.bpj.2019.04.022] [PMID: 31103225]
[19]
Jiang Z, Harrington P, Zhang M, et al. Effects of High Hydrostatic Pressure on Expression Profiles of In Vitro Produced Vitrified Bovine Blastocysts. Sci Rep 2016; 6: 21215.
[http://dx.doi.org/10.1038/srep21215] [PMID: 26883277]
[20]
Kimura H, Nishikawa M, Yanagawa N, et al. Effect of fluid shear stress on in vitro cultured ureteric bud cells. Biomicrofluidics 2018; 12(4)044107
[http://dx.doi.org/10.1063/1.5035328] [PMID: 30034570]
[21]
Olcum M, Ozcivici E. Daily application of low magnitude mechanical stimulus inhibits the growth of MDA-MB-231 breast cancer cells in vitro. Cancer Cell Int 2014; 14(1): 102.
[http://dx.doi.org/10.1186/s12935-014-0102-z] [PMID: 25349533]
[22]
Pagnotti GM, Adler BJ, Green DE, et al. Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer. Bone 2012; 51(3): 570-7.
[http://dx.doi.org/10.1016/j.bone.2012.05.004] [PMID: 22584009]
[23]
Ozcivici E, Garman R, Judex S. High-frequency oscillatory motions enhance the simulated mechanical properties of non-weight bearing trabecular bone. J Biomech 2007; 40(15): 3404-11.
[http://dx.doi.org/10.1016/j.jbiomech.2007.05.015] [PMID: 17655852]
[24]
Lau E, Al-Dujaili S, Guenther A, Liu D, Wang L, You L. Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts. Bone 2010; 46(6): 1508-15.
[http://dx.doi.org/10.1016/j.bone.2010.02.031] [PMID: 20211285]
[25]
Ozcivici E, Luu YK, Rubin CT, Judex S. Low-level vibrations retain bone marrow’s osteogenic potential and augment recovery of trabecular bone during reambulation. PLoS One 2010; 5(6)e11178
[http://dx.doi.org/10.1371/journal.pone.0011178] [PMID: 20567514]
[26]
Shikata T, Shiraishi T, Morishita S, Takeuchi R, Saito T. Effects of Amplitude and Frequency of Mechanical Vibration Stimulation on Cultured Osteoblasts. Journal of System Design and Dynamics 2008; 2(1): 382-8.
[http://dx.doi.org/10.1299/jsdd.2.382]
[27]
Olcum M, Baskan O, Karadas O, Ozcivici E. Application of low intensity mechanical vibrations for bone tissue maintenance and regeneration. Turk J Biol 2016; 40(2): 300-7.
[http://dx.doi.org/10.3906/biy-1506-76]
[28]
Kim H-J, Kim J-H, Song Y-J, Seo Y-K, Park J-K, Kim C-W. Overexpressed Calponin3 by Subsonic Vibration Induces Neural Differentiation of hUC-MSCs by Regulating the Ionotropic Glutamate Receptor. Appl Biochem Biotechnol 2015; 177(1): 48-62.
[http://dx.doi.org/10.1007/s12010-015-1726-8] [PMID: 26175098]
[29]
El-Danasouri I, Sandi-Monroy NL, Winkle T, et al. Micro-vibration culture of human embryos improves pregnancy and implantation rates. Fertil Steril 2014; 102(3)e217
[http://dx.doi.org/10.1016/j.fertnstert.2014.07.732]
[30]
Hur YS, Park JH, Ryu EK, et al. Effect of micro-vibration culture system on embryo development. J Assist Reprod Genet 2013; 30(6): 835-41.
[http://dx.doi.org/10.1007/s10815-013-0007-0] [PMID: 23657828]
[31]
Isachenko E, Maettner R, Isachenko V, Roth S, Kreienberg R, Sterzik K. Mechanical agitation during the in vitro culture of human pre-implantation embryos drastically increases the pregnancy rate. Clin Lab 2010; 56(11-12): 569-76.
[PMID: 21141442]
[32]
Zhang S, Tan Y, Ren Z, Zhang Y, Zhang S. A microchip laser feedback interferometer with nanometer resolution and increased measurement speed based on phase meter. Appl Phys B 2014; 116(3): 609-16.
[http://dx.doi.org/10.1007/s00340-013-5743-4]
[33]
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414(6859): 105-11.
[http://dx.doi.org/10.1038/35102167] [PMID: 11689955]
[34]
Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther 2019; 10(1): 68-8.
[http://dx.doi.org/10.1186/s13287-019-1165-5] [PMID: 30808416]
[35]
Abdal Dayem A, Lee SB, Kim K, et al. Production of Mesenchymal Stem Cells Through Stem Cell Reprogramming. Int J Mol Sci 2019; 20(8): 1922.
[http://dx.doi.org/10.3390/ijms20081922] [PMID: 31003536]
[36]
Laronda MM, Burdette JE, Kim J, Woodruff TK. Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment. Stem Cell Res Ther 2013; 4(1)(Suppl. 1): S13.
[http://dx.doi.org/10.1186/scrt374] [PMID: 24565375]
[37]
Anil-Inevi M, Yaman S, Yildiz AA, et al. Biofabrication of in situ Self Assembled 3D Cell Cultures in a Weightlessness Environment Generated using Magnetic Levitation. Sci Rep 2018; 8(1): 7239.
[http://dx.doi.org/10.1038/s41598-018-25718-9] [PMID: 29740095]
[38]
Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 2007; 213(2): 341-7.
[http://dx.doi.org/10.1002/jcp.21200] [PMID: 17620285]
[39]
Dawson E, Mapili G, Erickson K, Taqvi S, Roy K. Biomaterials for stem cell differentiation. Adv Drug Deliv Rev 2008; 60(2): 215-28.
[http://dx.doi.org/10.1016/j.addr.2007.08.037] [PMID: 17997187]
[40]
Gurkan UA, Akkus O. The mechanical environment of bone marrow: a review. Ann Biomed Eng 2008; 36(12): 1978-91.
[http://dx.doi.org/10.1007/s10439-008-9577-x] [PMID: 18855142]
[41]
Gardner OF, Alini M, Stoddart MJ. Mesenchymal Stem Cells Derived from Human Bone Marrow. Methods Mol Biol 2015; 1340: 41-52.
[http://dx.doi.org/10.1007/978-1-4939-2938-2_3] [PMID: 26445829]
[42]
Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep 2015; 35(2)e00191
[http://dx.doi.org/10.1042/BSR20150025] [PMID: 25797907]
[43]
Marion NW, Mao JJ. Mesenchymal stem cells and tissue engineering. Methods Enzymol 2006; 420: 339-61.
[http://dx.doi.org/10.1016/S0076-6879(06)20016-8] [PMID: 17161705]
[44]
Baskan O, Mese G, Ozcivici E. Low-intensity vibrations normalize adipogenesis-induced morphological and molecular changes of adult mesenchymal stem cells Proceedings of the Institution of Mechanical Engi-neers, Part H: Journal of Engineering in Medicine 0954411916687338.
[45]
Sarigil O, Anil-Inevi M, Yilmaz E, Mese G, Tekin HC, Ozcivici E. Label-free density-based detection of adipocytes of bone marrow origin using magnetic levitation. Analyst (Lond) 2019; 144(9): 2942-53.
[http://dx.doi.org/10.1039/C8AN02503G] [PMID: 30939180]
[46]
Demiray L, Ozcivici E. Bone marrow stem cells adapt to low-magnitude vibrations by altering their cytoskeleton during quiescence and osteogenesis. Turk J Biol 2015; 39(1): 88-97.
[http://dx.doi.org/10.3906/biy-1404-35]
[47]
Chen B, Lin T, Yang X, et al. Low-magnitude, high-frequency vibration promotes the adhesion and the osteogenic differentiation of bone marrow-derived mesenchymal stem cells cultured on a hydroxyapatite-coated surface: The direct role of Wnt/β-catenin signaling pathway activation. Int J Mol Med 2016; 38(5): 1531-40.
[http://dx.doi.org/10.3892/ijmm.2016.2757] [PMID: 28026000]
[48]
Zhao Q, Lu Y, Gan X, Yu H. Low magnitude high frequency vibration promotes adipogenic differentiation of bone marrow stem cells via P38 MAPK signal. PLoS One 2017; 12(3)e0172954
[http://dx.doi.org/10.1371/journal.pone.0172954] [PMID: 28253368]
[49]
Lu Y, Zhao Q, Liu Y, et al. Vibration loading promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells via p38 MAPK signaling pathway. J Biomech 2018; 71: 67-75.
[http://dx.doi.org/10.1016/j.jbiomech.2018.01.039] [PMID: 29503016]
[50]
Kim IS, Song YM, Lee B, Hwang SJ. Human mesenchymal stromal cells are mechanosensitive to vibration stimuli. J Dent Res 2012; 91(12): 1135-40.
[http://dx.doi.org/10.1177/0022034512465291] [PMID: 23086742]
[51]
Chen X, He F, Zhong D-Y, Luo Z-P. Acoustic-frequency vibratory stimulation regulates the balance between osteogenesis and adipogenesis of human bone marrow-derived mesenchymal stem cells. BioMed Res Int 2015; 2015: 540731-1.
[http://dx.doi.org/10.1155/2015/540731] [PMID: 25738155]
[52]
Prè D, Ceccarelli G, Visai L, et al. High-Frequency Vibration Treatment of Human Bone Marrow Stromal Cells Increases Differentiation toward Bone Tissue. Bone Marrow Res 2013; 2013: 803450-0.
[http://dx.doi.org/10.1155/2013/803450] [PMID: 23585968]
[53]
Nikolaev NI, Liu Y, Hussein H, Williams DJ. The sensitivity of human mesenchymal stem cells to vibration and cold storage conditions representative of cold transportation. J R Soc Interface 2012; 9(75): 2503-15.
[http://dx.doi.org/10.1098/rsif.2012.0271] [PMID: 22628214]
[54]
Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived stem cells: isolation, expansion and differentiation. Methods 2008; 45(2): 115-20.
[http://dx.doi.org/10.1016/j.ymeth.2008.03.006] [PMID: 18593609]
[55]
Frese L, Dijkman PE, Hoerstrup SP. Adipose Tissue-Derived Stem Cells in Regenerative Medicine. Transfus Med Hemother 2016; 43(4): 268-74.
[http://dx.doi.org/10.1159/000448180] [PMID: 27721702]
[56]
Marędziak M, Lewandowski D, Tomaszewski KA, Kubiak K, Marycz K. The Effect of Low-Magnitude Low-Frequency Vibrations (LMLF) on Osteogenic Differentiation Potential of Human Adipose Derived Mesenchymal Stem Cells. Cell Mol Bioeng 2017; 10(6): 549-62.
[http://dx.doi.org/10.1007/s12195-017-0501-z] [PMID: 29151982]
[57]
Marycz K, Lewandowski D, Tomaszewski KA, Henry BM, Golec EB, Marędziak M. Low-frequency, low-magnitude vibrations (LFLM) enhances chondrogenic differentiation potential of human adipose derived mesenchymal stromal stem cells (hASCs). PeerJ 2016; 4e1637
[http://dx.doi.org/10.7717/peerj.1637] [PMID: 26966645]
[58]
Tirkkonen L, Halonen H, Hyttinen J, et al. The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells. J R Soc Interface 2011; 8(65): 1736-47.
[http://dx.doi.org/10.1098/rsif.2011.0211] [PMID: 21613288]
[59]
Prè D, Ceccarelli G, Gastaldi G, et al. The differentiation of human adipose-derived stem cells (hASCs) into osteoblasts is promoted by low amplitude, high frequency vibration treatment. Bone 2011; 49(2): 295-303.
[http://dx.doi.org/10.1016/j.bone.2011.04.013] [PMID: 21550433]
[60]
Choi YK, Cho H, Seo YK, Yoon HH, Park JK. Stimulation of sub-sonic vibration promotes the differentiation of adipose tissue-derived mesenchymal stem cells into neural cells. Life Sci 2012; 91(9-10): 329-37.
[http://dx.doi.org/10.1016/j.lfs.2012.07.022] [PMID: 22884804]
[61]
Cho H, Seo Y-K, Jeon S, Yoon H-H, Choi Y-K, Park J-K. Neural differentiation of umbilical cord mesenchymal stem cells by sub-sonic vibration. Life Sci 2012; 90(15-16): 591-9.
[http://dx.doi.org/10.1016/j.lfs.2012.02.014] [PMID: 22406078]
[62]
Edwards J, Reilly G. Low magnitude, high frequency vibration modulates mesen-chymal progenitor differentiation Trans Annu Meet Orthop Res Soc 2011; 57.
[63]
Dulak J, Szade K, Szade A, Nowak W, Józkowicz A. Adult stem cells: hopes and hypes of regenerative medicine. Acta Biochim Pol 2015; 62(3): 329-37.
[http://dx.doi.org/10.18388/abp.2015_1023] [PMID: 26200199]
[64]
Oh E-S, Seo Y-K, Yoon H-H, Cho H, Yoon M-Y, Park J-K. Effects of sub-sonic vibration on the proliferation and maturation of 3T3-L1 cells. Life Sci 2011; 88(3-4): 169-77.
[http://dx.doi.org/10.1016/j.lfs.2010.11.007] [PMID: 21062628]
[65]
Gao H, Zhai M, Wang P, et al. Low‑level mechanical vibration enhances osteoblastogenesis via a canonical Wnt signaling‑associated mechanism. Mol Med Rep 2017; 16(1): 317-24.
[http://dx.doi.org/10.3892/mmr.2017.6608] [PMID: 28534995]
[66]
Zhang Y, Hou W, Liu Y, et al. Microvibration stimulates β-catenin expression and promotes osteogenic differentiation in osteoblasts. Arch Oral Biol 2016; 70: 47-54.
[http://dx.doi.org/10.1016/j.archoralbio.2016.06.009] [PMID: 27328150]
[67]
Ota T, Chiba M, Hayashi H. Vibrational stimulation induces osteoblast differentiation and the upregulation of osteogenic gene expression in vitro. Cytotechnology 2016; 68(6): 2287-99.
[http://dx.doi.org/10.1007/s10616-016-0023-x] [PMID: 27639712]
[68]
Pongkitwitoon S, Weinheimer-Haus EM, Koh TJ, Judex S. Low-intensity vibrations accelerate proliferation and alter macrophage phenotype in vitro. J Biomech 2016; 49(5): 793-6.
[http://dx.doi.org/10.1016/j.jbiomech.2016.01.027] [PMID: 26897645]
[69]
Shafieyan Y, Tiedemann K, Komarova SV, Quinn TM. Effects of low frequency cyclic mechanical stretching on osteoclastogenesis. J Biomech 2014; 47(15): 3750-7.
[http://dx.doi.org/10.1016/j.jbiomech.2014.06.028] [PMID: 25443781]
[70]
Chen F-M, Gao L-N, Tian B-M, et al. Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial. Stem Cell Res Ther 2016; 7(1): 33.
[http://dx.doi.org/10.1186/s13287-016-0288-1] [PMID: 26895633]
[71]
Seo B-M, Miura M, Gronthos S, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004; 364(9429): 149-55.
[http://dx.doi.org/10.1016/S0140-6736(04)16627-0] [PMID: 15246727]
[72]
Benjakul S, Jitpukdeebodintra S, Leethanakul C. Effects of low magnitude high frequency mechanical vibration combined with compressive force on human periodontal ligament cells in vitro. Eur J Orthod 2018; 40(4): 356-63.
[http://dx.doi.org/10.1093/ejo/cjx062] [PMID: 29016746]
[73]
Zhang C, Lu Y, Zhang L, et al. Influence of different intensities of vibration on proliferation and differentiation of human periodontal ligament stem cells. Arch Med Sci 2015; 11(3): 638-46.
[http://dx.doi.org/10.5114/aoms.2015.52370] [PMID: 26170859]
[74]
Shen T, Qiu L, Chang H, et al. Cyclic tension promotes osteogenic differentiation in human periodontal ligament stem cells. Int J Clin Exp Pathol 2014; 7(11): 7872-80.
[PMID: 25550827]
[75]
Zhang C, Li J, Zhang L, et al. Effects of mechanical vibration on proliferation and osteogenic differentiation of human periodontal ligament stem cells. Arch Oral Biol 2012; 57(10): 1395-407.
[http://dx.doi.org/10.1016/j.archoralbio.2012.04.010] [PMID: 22595622]
[76]
Tang N, Zhao Z, Zhang L, et al. Up-regulated osteogenic transcription factors during early response of human periodontal ligament stem cells to cyclic tensile strain. Arch Med Sci 2012; 8(3): 422-30.
[http://dx.doi.org/10.5114/aoms.2012.28810] [PMID: 22851995]
[77]
Uzer G, Bas G, Sen B, et al. Sun-mediated mechanical LINC between nucleus and cytoskeleton regulates βcatenin nuclear access. J Biomech 2018; 74: 32-40.
[http://dx.doi.org/10.1016/j.jbiomech.2018.04.013] [PMID: 29691054]
[78]
Tajik A, Zhang Y, Wei F, et al. Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater 2016; 15(12): 1287-96.
[http://dx.doi.org/10.1038/nmat4729] [PMID: 27548707]
[79]
Le HQ, Ghatak S, Yeung CY, et al. Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol 2016; 18(8): 864-75.
[http://dx.doi.org/10.1038/ncb3387] [PMID: 27398909]
[80]
Uzer G, Thompson WR, Sen B, et al. Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus. Stem Cells 2015; 33(6): 2063-76.
[http://dx.doi.org/10.1002/stem.2004] [PMID: 25787126]
[81]
Sen B, Xie Z, Case N, Styner M, Rubin CT, Rubin J. Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. J Biomech 2011; 44(4): 593-9.
[http://dx.doi.org/10.1016/j.jbiomech.2010.11.022] [PMID: 21130997]
[82]
Hou WW, Zhu ZL, Zhou Y, Zhang CX, Yu HY. Involvement of Wnt activation in the micromechanical vibration-enhanced osteogenic response of osteoblasts. J Orthop Sci 2011; 16(5): 598-605.
[http://dx.doi.org/10.1007/s00776-011-0124-5] [PMID: 21833614]
[83]
Duval K, Grover H, Han LH, et al. Modeling Physiological Events in 2D vs. 3D Cell Culture. Physiology (Bethesda) 2017; 32(4): 266-77.
[http://dx.doi.org/10.1152/physiol.00036.2016] [PMID: 28615311]
[84]
Karadas O, Mese G, Ozcivici E. Cytotoxic Tolerance of Healthy and Cancerous Bone Cells to Anti-microbial Phenolic Compounds Depend on Culture Conditions. Appl Biochem Biotechnol 2019; 188(2): 514-26.
[http://dx.doi.org/10.1007/s12010-018-02934-7] [PMID: 30536030]
[85]
Ince Yardimci A, Baskan O, Yilmaz S, Mese G, Ozcivici E, Selamet Y. Osteogenic differentiation of mesenchymal stem cells on random and aligned PAN/PPy nanofibrous scaffolds. J Biomater Appl 2019; 34(5): 640-50.
[http://dx.doi.org/10.1177/0885328219865068] [PMID: 31342834]
[86]
Tsimbouri PM, Childs PG, Pemberton GD, et al. Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor. Nat Biomed Eng 2017; 1(9): 758-70.
[http://dx.doi.org/10.1038/s41551-017-0127-4] [PMID: 31015671]
[87]
Mehta S, McClarren B, Aijaz A, Chalaby R, Cook-Chennault K, Olabisi RM. The effect of low-magnitude, high-frequency vibration on poly(ethylene glycol)-microencapsulated mesenchymal stem cells. J Tissue Eng 2018; 92041731418800101
[88]
Bartlett RS, Gaston JD, Ye S, Kendziorski C, Thibeault SL. Mechanotransduction of vocal fold fibroblasts and mesenchymal stromal cells in the context of the vocal fold mechanome. J Biomech 2019; 83: 227-34.
[http://dx.doi.org/10.1016/j.jbiomech.2018.11.050] [PMID: 30553439]
[89]
Wolchok JC, Brokopp C, Underwood CJ, Tresco PA. The effect of bioreactor induced vibrational stimulation on extracellular matrix production from human derived fibroblasts. Biomaterials 2009; 30(3): 327-35.
[http://dx.doi.org/10.1016/j.biomaterials.2008.08.035] [PMID: 18937972]
[90]
Titze IR, Hitchcock RW, Broadhead K, et al. Design and validation of a bioreactor for engineering vocal fold tissues under combined tensile and vibrational stresses. J Biomech 2004; 37(10): 1521-9.
[http://dx.doi.org/10.1016/j.jbiomech.2004.01.007] [PMID: 15336927]
[91]
Tong Z, Zerdoum AB, Duncan RL, Jia X. Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors. Tissue Eng Part A 2014; 20(13-14): 1922-34.
[http://dx.doi.org/10.1089/ten.tea.2013.0496] [PMID: 24456068]
[92]
Zhou Y, Guan X, Zhu Z, et al. Osteogenic differentiation of bone marrow-derived mesenchymal stromal cells on bone-derived scaffolds: effect of microvibration and role of ERK1/2 activation. Eur Cell Mater 2011; 22: 12-25.
[http://dx.doi.org/10.22203/eCM.v022a02] [PMID: 21732279]
[93]
He S, Zhao W, Zhang L, et al. Low-frequency vibration treatment of bone marrow stromal cells induces bone repair in vivo. Iran J Basic Med Sci 2017; 20(1): 23-8.
[PMID: 28133520]
[94]
Curtis KJ, Coughlin TR, Mason DE, Boerckel JD, Niebur GL. Bone marrow mechanotransduction in porcine explants alters kinase activation and enhances trabecular bone formation in the absence of osteocyte signaling. Bone 2018; 107: 78-87.
[http://dx.doi.org/10.1016/j.bone.2017.11.007] [PMID: 29154967]

Rights & Permissions Print Cite
Article Metrics
30
2
© 2024 Bentham Science Publishers | Privacy Policy