Non-coding RNAs can be highly exploited for their biological significance in
living systems. miRNAs are in the upstream position of cellular regulation cascade and
hold merit in its state. A plethora of information is available on a wide variety of miRNAs
that undergo alterations in experimentally induced models of liver injuries. The
underlying mechanisms governed by these miRNAs have been inferred through cellbased
experiments but the scientific knowledge on miRNA signatures in patients with
liver injury are primordial and lack scientific clarity. Hence, it is crucial to get insight into
the status and synergy of miRNAs in patients, with varying degrees of acute toxic
manifestations in the liver. Though some miRNAs are being investigated in clinical trials,
a major research lacuna exists with regard to the functional role of other miRNAs in liver
diseases. This review article is a meticulous compilation of disease based or
drug/alcohol based acute liver injuries in patients and resultant alteration in their miRNA
profile. Investigative reports on underlying miRNA-liver crosstalk in cell-based or murine
models are also discussed herein to draw a correlation with clinical findings.
Keywords: microRNAs, acute liver injury, patients, biomarker, cirrhosis.
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