Association between Single-nucleotide Polymorphisms of RXRG and Genetic Susceptibility to Type 2 Diabetes in South China

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Author(s): Haibing Yu, Shu Wang, Wei Hu, Lin Xu, Yuanlin Ding, Danli Kong, Haiyan Pan*.

Journal Name: Current Molecular Medicine

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Objective: To Investigate The Relationship Between Genetic Polymorphisms Of Rxrg Rs1467664, Rs3753898 And The Genetic Susceptibility Of Type 2 Diabetes In Chinese Han Population From South China.

Methods: In Our Case-Control Study, Single-Nucleotide Polymorphisms (Snps) Rs1467664 And Rs3753898 Were Genotyped By Snpscantm Kit In 1092 Patients With T2d As Cases And 1092 Normal Persons As Controls. The Distributions Of Genotype And Allele Frequencies In Two Groups Was Analyzed By Spss 20.0 Software.

Results: The Distribution Of Genotypes And Alleles Of Rxrg Rs3753898 Was Statistically Significant Between Two Groups, But There Was No Significant Difference In The Distribution Of Genotypes And Alleles Of The Rs1467664. Before And After The Adjustment Of Age, Sex And Bmi, Rs3753898 In The Two Groups Had Statistical Significance Under The Additive, Dominant And Recessive Models (P<0.05), But No Statistical Differences Were Found Under The Overdominance And Co-Dominant Genetic Models (P>0.05). There Was No Significant Difference In The Genetic Models Of Rs1467664 Between The Two Groups (P>0.05). The Haplotype Which Consists Of Rs1467664 Allele T And Rs3753898 Allele A Was A High Risk Factor For T2d, Or=1.27, 95% Ci (1.09-1.47), Padj=0.002.

Conclusion: Our Results Showed That The Single Nucleotide Polymorphism Of Rxrg Rs3753898 May Be Related To The Genetic Susceptibility Of Type 2 Diabetes. The Haplotype Consisting Of The Allele T Of Rs1467664 And The Allele A Of Rs3753898 Is A Risk Factor For Type 2 Diabetes, Suggesting That Genetic Variation Of Rxrg Gene May Be The Genetic Cause Of Diabetes Mellitus In Chinese Han Population.

Keywords: Type 2 diabetes (T2D), Single nucleotide polymorphisms (SNP), Retinoid X receptor gamma (RXRG), Chinese Han population

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(E-pub Ahead of Print)
DOI: 10.2174/1566524020666191206163951
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