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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Mini-Review Article

Epicardial Fat: A New Therapeutic Target in Psoriasis

Author(s): Preetha Kamath, Gabrielle Benesh, Paolo Romanelli and Gianluca Iacobellis *

Volume 25, Issue 46, 2019

Page: [4914 - 4918] Pages: 5

DOI: 10.2174/1381612825666191206091105

Price: $65

Abstract

Psoriasis is a chronic inflammatory disease affecting over 8 million Americans. Importantly, patients with psoriasis are at an increased risk of developing atherosclerosis, coronary artery disease, and myocardial infarctions. Several studies have suggested that psoriasis may be an independent risk factor for cardiovascular disease given their shared inflammatory properties and pathogenic similarities. Epicardial fat is also linked to cardiovascular disease and may be an independent risk factor for atherosclerosis. It has been proposed that measuring epicardial fat tissue may serve as a useful subclinical measure of cardiovascular disease in psoriasis patients. Echocardiography has been increasingly adopted as an accurate, minimally invasive, and cost-effective measure of determining the volume and thickness of epicardial fat. Using echocardiographic measures of epicardial fat thickness as a marker of cardiovascular disease and therapeutic target in psoriasis patients may provide clinicians with a means to better manage and hopefully prevent deleterious downstream effects.

Keywords: Psoriasis, epicardial fat tissue, epicardial adipose tissue, cardiovascular disease, echocardiography, atherosclerosis.

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[1]
Elmets CA, Leonardi CL, Davis DMR, et al. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities. J Am Acad Dermatol 2019; 80(4): 1073-113.
[http://dx.doi.org/10.1016/j.jaad.2018.11.058] [PMID: 30772097]
[2]
Brezinski EA, Dhillon JS, Armstrong AW. Economic burden of psoriasis in the United States: a systematic review. JAMA Dermatol 2015; 151(6): 651-8.
[http://dx.doi.org/10.1001/jamadermatol.2014.3593] [PMID: 25565304]
[3]
Sajja AP, Joshi AA, Teague HL, Dey AK, Mehta NN. Potential immunological links between psoriasis and cardiovascular disease. Front Immunol 2018; 9: 1234.
[http://dx.doi.org/10.3389/fimmu.2018.01234] [PMID: 29910818]
[4]
Semenov YR, Herbosa CM, Rogers AT, et al. Psoriasis and mortality in the US: data from the national health and nutrition examination survey. J Am Acad Dermatol 2019; pii: S0190-9622(19)32558- 7.
[http://dx.doi.org/10.1016/j.jaad.2019.08.011] [PMID: 31415837]
[5]
Hu SC, Lan CE. Psoriasis and cardiovascular comorbidities: focusing on severe vascular events, cardiovascular risk factors and implications for treatment. Int J Mol Sci 2017; 18(10) E2211
[http://dx.doi.org/10.3390/ijms18102211] [PMID: 29065479]
[6]
Raaby L, Ahlehoff O, de Thurah A. Psoriasis and cardiovascular events: updating the evidence. Arch Dermatol Res 2017; 309(3): 225-8.
[http://dx.doi.org/10.1007/s00403-016-1712-1] [PMID: 28213804]
[7]
Torres T, Bettencourt N, Ferreira J, et al. Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis. Br J Dermatol 2015; 172(2): 534-6.
[http://dx.doi.org/10.1111/bjd.13271] [PMID: 25040543]
[8]
Kremers HM, McEvoy MT, Dann FJ, Gabriel SE. Heart disease in psoriasis. J Am Acad Dermatol 2007; 57(2): 347-54.
[http://dx.doi.org/10.1016/j.jaad.2007.02.007] [PMID: 17433490]
[9]
Baumer Y, Ng Q, Sanda GE, et al. Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis. JCI Insight 2018; 3(1): 97179.
[http://dx.doi.org/10.1172/jci.insight.97179] [PMID: 29321372]
[10]
Iacobellis G. Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol 2015; 11(6): 363-71.
[http://dx.doi.org/10.1038/nrendo.2015.58] [PMID: 25850659]
[11]
Chechi K, Blanchard PG, Mathieu P, Deshaies Y, Richard D. Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease. Int J Cardiol 2013; 167(5): 2264-70.
[http://dx.doi.org/10.1016/j.ijcard.2012.06.008] [PMID: 22727960]
[12]
Sacks HS, Fain JN. Human epicardial adipose tissue: a review. Am Heart J 2007; 153(6): 907-17.
[http://dx.doi.org/10.1016/j.ahj.2007.03.019] [PMID: 17540190]
[13]
Iacobellis G, Barbaro G. The double role of epicardial adipose tissue as pro- and anti-inflammatory organ. Horm Metab Res 2008; 40(7): 442-5.
[http://dx.doi.org/10.1055/s-2008-1062724] [PMID: 18401833]
[14]
Wang X, Guo Z, Zhu Z, Bao Y, Yang B. Epicardial fat tissue in patients with psoriasis: a systematic review and meta-analysis. Lipids Health Dis 2016; 15: 103.
[http://dx.doi.org/10.1186/s12944-016-0271-y] [PMID: 27245937]
[15]
Salazar J, Luzardo E, Mejías JC, et al. Epicardial fat: physiological, pathological, and therapeutic implications. Cardiol Res Pract 2016; 2016 1291537
[http://dx.doi.org/10.1155/2016/1291537] [PMID: 27213076]
[16]
Gauss S, Klinghammer L, Steinhoff A, et al. Association of systemic inflammation with epicardial fat and coronary artery calcification. Inflamm Res 2015; 64(5): 313-9.
[http://dx.doi.org/10.1007/s00011-015-0809-x] [PMID: 25763815]
[17]
Wu Y, Zhang A, Hamilton DJ, Deng T. Epicardial fat in the maintenance of cardiovascular health. Methodist DeBakey Cardiovasc J 2017; 13(1): 20-4.
[http://dx.doi.org/10.14797/mdcj-13-1-20] [PMID: 28413578]
[18]
Iacobellis G. Epicardial fat: a new cardiovascular therapeutic target. Curr Opin Pharmacol 2016; 27: 13-8.
[http://dx.doi.org/10.1016/j.coph.2016.01.004] [PMID: 26848943]
[19]
Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr 2009; 22(12): 1311-9.
[http://dx.doi.org/10.1016/j.echo.2009.10.013] [PMID: 19944955]
[20]
Balta I, Balta S, Ozturk C, Demirkol S, Demir M. Epicardial fat thickness in psoriasis patients. Dermatology (Basel) 2014; 228(2): 132-3.
[http://dx.doi.org/10.1159/000357403] [PMID: 24516065]
[21]
Iacobellis G, Assael F, Ribaudo MC, et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 2003; 11(2): 304-10.
[http://dx.doi.org/10.1038/oby.2003.45] [PMID: 12582228]
[22]
Bulbul Sen B, Atci N, Rifaioglu EN, et al. Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis. Br J Dermatol 2013; 169(5): 1081-6.
[http://dx.doi.org/10.1111/bjd.12569] [PMID: 23909282]
[23]
Torres T, Bettencourt N, Mendonça D, et al. Epicardial adipose tissue and coronary artery calcification in psoriasis patients. J Eur Acad Dermatol Venereol 2015; 29(2): 270-7.
[http://dx.doi.org/10.1111/jdv.12516] [PMID: 24750319]
[24]
Balci A, Celik M, Balci DD, et al. Patients with psoriasis have an increased amount of epicardial fat tissue. Clin Exp Dermatol 2014; 39(2): 123-8.
[http://dx.doi.org/10.1111/ced.12216] [PMID: 24164295]
[25]
Momose M, Asahina A, Fukuda T, Sakuma T, Umezawa Y, Nakagawa H. Evaluation of epicardial adipose tissue volume and coronary artery calcification in Japanese patients with psoriasis vulgaris. J Dermatol 2018; 45(11): 1349-52.
[http://dx.doi.org/10.1111/1346-8138.14618] [PMID: 30152023]
[26]
Akyildiz ZI, Seremet S, Emren V, et al. Epicardial fat thickness is independently associated with psoriasis. Dermatology (Basel) 2014; 228(1): 55-9.
[http://dx.doi.org/10.1159/000354726] [PMID: 24158189]
[27]
Bacaksız A, Tasal A, Sevgili E, et al. Epicardial fat thickness in patients with psoriasis vulgaris. Turk Kardiyol Dern Ars 2014; 42(1): 47-54.
[http://dx.doi.org/10.5543/tkda.2014.78949] [PMID: 24481095]
[28]
Raposo I, Torres T. Psoriasis strikes back! Epicardial adipose tissue: another contributor to the higher cardiovascular risk in psoriasis. Rev Port Cardiol 2015; 34(10): 613-6.
[http://dx.doi.org/10.1016/j.repc.2015.04.007] [PMID: 26417656]
[29]
Suárez-Fariñas M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG. Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis. J Invest Dermatol 2012; 132(11): 2552-64.
[http://dx.doi.org/10.1038/jid.2012.184] [PMID: 22763790]
[30]
Baran A, Flisiak I, Jaroszewicz J, Świderska M. Effect of psoriasis activity on serum adiponectin and leptin levels. Postepy Dermatol Alergol 2015; 32(2): 101-6.
[http://dx.doi.org/10.5114/pdia.2014.40960] [PMID: 26015779]
[31]
Torres T, Bettencourt N, Ferreira J, et al. Lack of association between leptin, leptin receptor, adiponectin gene polymorphisms and epicardial adipose tissue, abdominal visceral fat volume and atherosclerotic burden in psoriasis patients. Arch Physiol Biochem 2015; 121(3): 103-8.
[http://dx.doi.org/10.3109/13813455.2015.1024136] [PMID: 26123401]
[32]
Torres T, Alexandre JM, Mendonça D, Vasconcelos C, Silva BM, Selores M. Levels of physical activity in patients with severe psoriasis: a cross-sectional questionnaire study. Am J Clin Dermatol 2014; 15(2): 129-35.
[http://dx.doi.org/10.1007/s40257-014-0061-0] [PMID: 24464933]
[33]
Bairapareddy KC, Maiya AG, Kumar P, Nayak K, Guddattu V, Nayak V. Effect of aerobic exercise on echocardiographic epicardial adipose tissue thickness in overweight individuals. Diabetes Metab Syndr Obes 2018; 11: 303-12.
[http://dx.doi.org/10.2147/DMSO.S145862] [PMID: 29950876]
[34]
Aksu F, Caliskan M, Keles N, et al. Chemerin as a marker of subclinical cardiac involvement in psoriatic patients. Cardiol J 2017; 24(3): 276-83.
[http://dx.doi.org/10.5603/CJ.a2017.0031] [PMID: 28353314]
[35]
Aksu F. The levels of vaspin and chemerin levels and correlation between cardiologic parametres in patients with psoriasis vulgaris. Clin Chem 2015; 61(10): S13.
[36]
Demircioglu K, Aksu F, Caliskan M, Yilmaz Y. Gamma-glutamyltransferase and markers of subclinical atherosclerosis in patients with psoriasis. Arterioscler Thromb Vasc Biol 2016; 36.
[37]
Torres T, Bettencourt N, Mendonça D, Vasconcelos C, Silva BM, Selores M. Complement C3 as a marker of cardiometabolic risk in psoriasis. Arch Dermatol Res 2014; 306(7): 653-60.
[http://dx.doi.org/10.1007/s00403-014-1467-5] [PMID: 24848273]
[38]
Packer M. Epicardial adipose tissue inflammation can cause the distinctive pattern of cardiovascular disorders seen in psoriasis Am J Med 2019; pii: S0002-9343(19)30750-8
[http://dx.doi.org/10.1016/j.amjmed.2019.08.027] [PMID: 31520623]
[39]
Sbidian E, Chaimani A, Garcia-Doval I, et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis Cochrane Database Syst Rev 2017; 12: CD011535
[http://dx.doi.org/10.1002/14651858.CD011535.pub2 ] [PMID: 29271481]
[40]
Gkalpakiotis S, Arenbergerova M, Gkalpakioti P, Potockova J, Arenberger P, Kraml P. Impact of adalimumab treatment on cardiovascular risk biomarkers in psoriasis: results of a pilot study. J Dermatol 2017; 44(4): 363-9.
[http://dx.doi.org/10.1111/1346-8138.13661] [PMID: 27774694]
[41]
Pina T, Genre F, Lopez-Mejias R, et al. Anti-TNF-α therapy reduces retinol-binding protein 4 serum levels in non-diabetic patients with psoriasis: a 6-month prospective study. J Eur Acad Dermatol Venereol 2016; 30(1): 92-5.
[http://dx.doi.org/10.1111/jdv.13005] [PMID: 25650695]
[42]
Ahlehoff O, Hansen PR, Gislason GH, et al. Myocardial function and effects of biologic therapy in patients with severe psoriasis: a prospective echocardiographic study. J Eur Acad Dermatol Venereol 2016; 30(5): 819-23.
[http://dx.doi.org/10.1111/jdv.13152] [PMID: 25845841]
[43]
Herédi E, Végh J, Pogácsás L, et al. Subclinical cardiovascular disease and it’s improvement after long-term TNF-α inhibitor therapy in severe psoriatic patients. J Eur Acad Dermatol Venereol 2016; 30(9): 1531-6.
[http://dx.doi.org/10.1111/jdv.13649] [PMID: 27393182]
[44]
Motolese A, Chiaravalloti V, Cerati M, Oldrini R, Mola F, Passi A. Interleukin levels and macrophagic density in periumbilical fat tissue in patients affected by moderate-to-severe psoriasis with metabolic syndrome, before and after etanercept treatment. G Ital Dermatol Venereol 2017; 152(4): 342-7.
[PMID: 27284777]
[45]
Kitagawa T, Yamamoto H, Hattori T, et al. Tumor necrosis factor-α gene expression in epicardial adipose tissue is related to coronary atherosclerosis assessed by computed tomography. J Atheroscler Thromb 2018; 25(3): 269-80.
[http://dx.doi.org/10.5551/jat.41178] [PMID: 28931782]

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