Progress in Target Drug Molecules for Alzheimer's Disease

Author(s): Jiayang Xie, Ruirui Liang, Yajiang Wang, Junyi Huang*, Xin Cao*, Bing Niu*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 1 , 2020

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Graphical Abstract:


Abstract:

Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although there are many researches on anti-AD drugs, they are limited to reverse relief symptoms and cannot treat diseases. Therefore, the development of high-efficiency anti-AD drugs with no side effects has become an urgent need. Based on the published literature, this paper summarizes the main targets of AD and their drugs, and focuses on the research and development progress of these drugs in recent years.

Keywords: Amyloid beta (Aβ), Acetylcholinesterase (AChE), Amyloid-beta binding alcohol dehydrogenase (ABAD), Butyrylcholinesterase (BChE), B-site APP cleaving enzyme 1 (BACE1), Cyclin-dependent kinase-5 (CDK-5), Glycogen synthase kinase-3β (GSK-3β), Monoamine oxidase (MAO), Tau protein.

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