The haywain: anti-synthethase antibodies in patients with inflammatory diseases: targeting monocytes or neutrophils?

(E-pub Abstract Ahead of Print)

Author(s): Bob Meek, Ger Rijkers*.

Journal Name: Current Medicinal Chemistry


Autoantibiodies against aminoacyl-tRNA synthetases are found in patients suffering from a wide range of autoimmune and inflammatory disorders. Recent data indicate that these antibodies are directed against splice-variants of synthetase genes, the so-called catalytic nulls. Latter molecules have cytokine-like functions and are involved in regulation of the activation of lymphocytes, monocytes and granulocytes. The potential role of anti-synthetase antibodies as diagnostic tool and as target for therapeutic interventions is discussed.

Keywords: Anti-Synthetase, Dermatomyositis, Polymyositis, Interstitial Lung Disease

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/0929867326666191128141215
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