Background: Left ventricular diastolic dysfunction (LVDD) is a common abnormality
among patients in T2DM.
Aims: We aimed to evaluate the feasibility of coronary computed tomography angiography
(CCTA) for the assessment of LVDD in type 2 diabetes mellitus (T2DM) patients.
Methods: 80 consecutive T2DM patients who were referred for a clinically dual-source CCTA
examination to evaluate suspected coronary artery disease and also underwent 2D echocardiography
within 7 days of CCTA inclusion and exclusion criteria, were performed. Correlation between
CCTA and echocardiography was tested through linear regression and Bland-Altman analysis.
Results: In total, 60 T2DM patients were included for the analysis. Pearson correlation showed
good correlation for E (r = 0.28; P = 0.028), E/A (r = 0.69; P < 0.01); E (r = -0.06; P = 0.776),
E/A (r = 0.54; P = 0.003) and E (r = 0.64; P < 0.01), E/A (r = 0.83; P < 0.01) in three groups, respectively.
Overall, diagnostic accuracy for assessment in CCTA of diastolic dysfunction was
79.76% (95% CI: 68%-91%), 71.43% (95% CI: 58%-85%) and 87.50 (95% CI: 79%-96%) in
Conclusion: The presented study proved that CCTA showed good correlations in the estimation
of LV filling pressures compared with echocardiography in T2DM patients. Accordingly, retrospectively
ECG-gated CCTA may provide valuable information on the evaluation of LVDD in