Saccharin (1,2-benzisothiazol-3(2H)-one-1,1-dioxide) is a very mild, cheap,
commercially available, water soluble, environmentally benign and edible Brønsted acidic
substance. Recently, with other utilities, saccharin and its derivatives were employed as
catalysts for various organic transformations. In this review, catalytic applicability of saccharin
and its derivatives under various reaction conditions is summarized.
Keywords: Green and sustainable synthesis, metal-free organo-catalysis, saccharin, saccharin sulfonic acid, sodium saccharin, DMAPsaccharin,
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