Cytotoxicity Through Molecular Targets Involved in Apoptosis. Where Should We Further Search for Mushrooms Functionalities in Future Cancer Treatment?
Pp. 146-191 (46)
Dejan Stojković, Jelena , Živković, Danijela , Stanisavljević, Marija Smiljković, Jelena Popović, Milena Stevanović, Jasmina Glamočlija and Marina Soković
Apoptosis is considered as a classical way of programmed cell death and
important control mechanism of cell homeostasis. Cancer cells acquire different
instruments to circumvent programmed cell death. This promotes uncontrolled growth
and frequently confers chemoresistance to tumor cells. Activation of apoptotic
signaling pathway has been a target of anti-cancer drugs in an induction of cytotoxicity.
The mechanism of apoptosis is complex and includes many pathways. This chapter will
focus on the current knowledge of apoptosis-triggering approaches in cancer therapy,
as well as on mushroom extracts and isolated compounds acting as initiators of
apoptosis through regulation of genes expression involved in cancer cell death.
Furthermore, we pointed out directions for novel search for mushroom functionalities
in this experimental field and discuss the possible further steps for exploration on the in
vitro and in vivo levels.
Cytotoxicity, Apoptosis, Molecular targets, Mushrooms, Cancer cells.
Department of Plant Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia.