Circulating miRNAs in Successful and Unsuccessful Aging. A Mini-review

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Author(s): Giuseppe Cammarata, Giovanni Duro*, Tiziana Di Chiara, Alessia Lo Curto, Simona Taverna, Giuseppina Candore.

Journal Name: Current Pharmaceutical Design


Aging is a multifactorial process that affects the organisms at genetic, molecular and cellular level. This process modifies several tissues with a negative impact on cells physiology, tissues and organs functionality, altering their regeneration capacity. The chronic low-grade inflammation typical of aging, defined as inflamm-aging, is a common biological factor responsible for decline and beginning of disease in age. A murine parabiosis model that combines the vascular system of old and young animals, suggests that soluble factors released by young individuals may improve the regenerative potential of old tissue. Therefore, circulating factors have a key role in the induction of aging phenotype. Moreover, lifestyle can influence the physiological status of multiple organs, via epigenetic mechanisms. Recently, microRNAs are considered potential sensors of aging.

Keywords: Circulating Mirnas, Aging, Exosome, Inflammation Mediators, Age-Related Diseases, Mir-21-5p, Mir-126

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(E-pub Ahead of Print)
DOI: 10.2174/1381612825666191119091644
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