Interleukin 1-beta is Linked to Chronic Low-grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents

(E-pub Abstract Ahead of Print)

Author(s): Gisele A. Amaral, Josilene D. Alves, Adenilda C. Honorio-França, Danny L. Fagundes, Gabriel Gomes Araujo, Nubia S. Lobato, Victor V. Lima, Fernanda R. Giachini*.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

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Abstract:

Aim: We hypothesized that IL-1β concentrations are augmented in overweight adolescents, who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β concentrations with several established risk factors for CVD.

Methods: Overweight or control subjects, aging from 14-18 years, were classified according their adjusted body mass index and evaluated for biochemical and anthropometric parameters. The pro-inflammatory cytokine IL-1β was assessed in serum.

Results: Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I index, IL-1β, and IL-8 levels, whereas were observed in overweight adolescents. No differences were observed in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol. Positive correlations between IL-1β with anthropometric and or biochemical parameters were found.

Conclusion: In conclusion, increased IL-1β levels correlate to dyslipidemic factors and may further support low-grade inflammation. IL-1β may further predict the early onset of cardiovascular disease within this population, taking into consideration its important regulatory role.

Keywords: Childhood, obesity, cytokine, inflammation, cardiovascular disease, dyslipemic factors

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1871530319666191116141159
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