Background: Zeolitic imidazolate frameworks with three metals Zn, Co and Ag (ZIF-
3M) and ZIF-67 were synthesized at room temperature and characterized with different techniques
such as FESEM, BET, EDX and XRD. Then, the synthesized nanoparticles were successfully applied
for the removal of levofloxacin from aqueous solutions.
Methods: To optimize the significant factors (i.e., pH, adsorbent dose and contact time), the response
surface methodology (RSM) was implemented based on Box-Behnken design (BBD) in each step, an
appropriate amount of adsorbent was added to 30 ppm of a solution containing levofloxacin and the
pH was adjusted to the desired value with 0.1 M HCl or 0.1 M NaOH. The mixture was stirred at
room temperature and then centrifuged at 7500 rpm for 3 min.
Results: The optimal conditions for each variable were performed using Box-Behnken design. Results
revealed that ZIF-3M nanoparticles more efficiently remove levofloxacin than ZIF-67 in aqueous
Conclusion: In this research, new three metals ZIF (ZIF-3M) nanoparticles were synthesized with
Ag, Zn and Co in aqueous solution and characterized by different techniques. Results indicated successful
synthesis with preserving ZIF framework. Results indicated that ZIF-3M has more ability for
the removal of levofloxacin than ZIF-67. Isotherm studies showed that the most suitable model for
the adsorption of levofloxacin onto ZIF-3M has a good agreement with the Langmuier model.