Ischemic stroke, which is the fifth leading cause of death, is an attack in the brain due to a blockage of a brain artery. It occurs when a sudden loss of blood flow to the brain leads to a reduction in the oxygen supply. A wide range of reasons has been found for ischemic stroke, including high blood pressure and associated thrombosis. Suitable biomarker analysis followed by proper treatment helps to prevent ischemic stroke. An aptamer is an artificial antibody generated against various clinical biomarkers from a smaller molecule of a whole cell. Recently, several researchers conducted biomarker analysis for ischemic stroke using aptamers. Furthermore, factor IX, which is a blood clotting factor, is highly correlated with thrombosis and plays a role in ischemic stroke. In this review, we summarized the potential role of aptamers in ischemic stroke by nanoscale analysis, and factor IX was the distinct focus of this review.
Keywords: Ischemic stroke, aptamer, biomarker, factor IX, thrombosis, nanoscale analysis
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