An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline-2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)-one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.
Keywords: 2-Amino-1, 4-naphthoquinone, 4-Aryl-3, 4-dihydrobenzo[g]quinoline-2, 5, 10(1H)-triones, Green synthesis, Meldrum’s acid, Substituted benzaldehydes, Three-component
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