An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g]quinoline-2,5,10(1H)-triones in Green Medium

(E-pub Abstract Ahead of Print)

Author(s): Saiedeh Kamalifar, Hamzeh Kiyani*.

Journal Name: Current Organic Chemistry

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Abstract:

An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline-2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)-one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

Keywords: 2-Amino-1, 4-naphthoquinone, 4-Aryl-3, 4-dihydrobenzo[g]quinoline-2, 5, 10(1H)-triones, Green synthesis, Meldrum’s acid, Substituted benzaldehydes, Three-component

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1385272823666191108123330
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