Affective-related disorders, including depression, are constantly rising, complicating
people’s personal lifestyle increasing disqualification and hospital care. Because of the high intensity
of urbanization, our lifestyle and food have altered dramatically in the last twenty years. These
food modifications have been associated with scores of depression and other affective-related disorders
in urbanized countries with high economic levels. Nutrients imbalance is considered as one of
the critical causes enabling the pathophysiological mechanisms for the development of psychiatric
disorders. The application of additional nutritional interventions for treatment of mood deteriorations
can be beneficial for both the prophylaxis and therapy of affective-related disorders. This paper
will review recent research on the relation of Vitamin D levels and the epidemiology of depression
In this paper, we will provide an overview of the results of a variety of different studies taking into
account research which both suggests and refutes an association. Based on these findings we will
propose important directions for future research in relation to this topic.
Keywords: Vitamin D, brain, depression, mood, affective-related disorders, aging, women.
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