The Functional Significance of Endocrine-immune Interactions in Health and Disease

Author(s): Sridhar Muthusami*, Balasubramanian Vidya, Esaki M Shankar, Jamuna Vadivelu, Ilangovan Ramachandran, Jone A Stanley, Nagarajan Selvamurugan.

Journal Name: Current Protein & Peptide Science

Volume 21 , Issue 1 , 2020

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Graphical Abstract:


Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.

Keywords: Immune system, endocrine system, protein, peptide, cross talk, hormones.

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Year: 2020
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DOI: 10.2174/1389203720666191106113435
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