Application of Genome-Wide Association Studies in Coronary Artery Disease

Author(s): Huilei Zheng, Zhiyu Zeng*, Hong Wen, Peng Wang, Chunxia Huang, Ping Huang, Qingyun Chen, Danping Gong, Xiaoling Qiu.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 40 , 2019


Abstract:

Coronary artery disease (CAD) is a complex disease caused by the combination of environmental and genetic factors. It is one of the leading causes of death and disability in the world. Much research has been focussed on CAD genetic mechanism. In recent years, genome-wide association study (GWAS) has developed rapidly around the world. Medical researchers around the world have successfully discovered a series of CAD genetic susceptibility genes or susceptible loci using medical research strategies, leading CAD research toward a new stage. This paper briefly summarizes the important progress made by GWAS for CAD in the world in recent years, and then analyzes the challenges faced by GWAS at this stage and the development trend of future research, to promote the transformation of genetic research results into clinical practice and provide guidance for further exploration of the genetic mechanism of CAD.

Keywords: Genome-wide association study, coronary artery disease, genetic susceptibility locus, single nucleotide polymorphism, genetic factors, genetic mechanism.

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