Coronary artery disease (CAD) is a complex disease caused by the combination of environmental and
genetic factors. It is one of the leading causes of death and disability in the world. Much research has been focussed
on CAD genetic mechanism. In recent years, genome-wide association study (GWAS) has developed
rapidly around the world. Medical researchers around the world have successfully discovered a series of CAD
genetic susceptibility genes or susceptible loci using medical research strategies, leading CAD research toward a
new stage. This paper briefly summarizes the important progress made by GWAS for CAD in the world in recent
years, and then analyzes the challenges faced by GWAS at this stage and the development trend of future research,
to promote the transformation of genetic research results into clinical practice and provide guidance for
further exploration of the genetic mechanism of CAD.
Keywords: Genome-wide association study, coronary artery disease, genetic susceptibility locus, single nucleotide polymorphism, genetic
factors, genetic mechanism.
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