Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics

(E-pub Ahead of Print)

Author(s): Ponnurengam Malliappan Sivakumar, Matin Islami, Ali Zarrabi*, Arezoo Khosravi, Shohreh Peimanfard.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

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Abstract:

Background and objective: Graphene-based nanomaterials have received increasing attention due to their unique physical–chemical properties including two-dimensional planar structure, large surface area, chemical and mechanical stability, super conductivity and good biocompatibility. On the other hand, graphene-based nanomaterials have been explored as theranostics agents, the combination of therapeutics and diagnostics. In recent years, grafting hydrophilic polymer moieties has been introduced as an efficient approach to improve the properties of graphene based nanomaterials and obtain new nanoassemblies for cancer therapy.

Methods and results: This review would illustrate biodistribution, cellular uptake and toxicity of polymer-graphene nanoassemblies and summarize part of successes achieved in cancer treatment using such nanoassemblies.

Conclusion: The observations showed successful targeting functionality of the polymer-GO conjugations and demonstrated reduction of the side effects of anti-cancer drugs for normal tissues.

Keywords: Cancer, graphene nanoassemblies, drug delivery, polymer, theranostics, hydrophilic polymer moieties

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1871520619666191028112258
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