Benzene is a six-membered hydrocarbon ring system and if three carbon-hydrogen units of benzene
ring are replaced by nitrogen atoms then triazine is formed. Triazines are present in three isomeric forms 1,2,3-
triazine, 1,2,4-triazine, and 1,3,5-triazine according to the position of the nitrogen atom. These are weak bases
having weaker resonance energy than benzene, so nucleophilic substitution is preferred than electrophilic substitution.
Triazine is an interesting class of heterocyclic compounds in medicinal chemistry. Numerous synthetic
derivatives of triazine have been prepared and evaluated for a wide spectrum of biological activities in different
models with desired findings such as antibacterial, antifungal, anti-cancer, antiviral, antimalarial, antiinflammatory,
antiulcer, anticonvulsant, antimicrobial, insecticidal and herbicidal agents. Triazine analogs have
exposed potent pharmacological activity. So, triazine nucleus may be considered as an interesting core moiety
for researchers for the development of future drugs.