A Concise Account on Eco-friendly Synthetic Strategies for Pyrazole Heterocycles

Author(s): Pargat Singh, Mahendra Nath*.

Journal Name: Current Green Chemistry

Volume 6 , Issue 3 , 2019

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Graphical Abstract:


Five membered nitrogen heterocycles are historically known to exhibit diverse therapeutic properties. In particular, the pyrazole analogues have shown a wide range of pharmacological profiles and a number of drugs containing this scaffold approved for the treatment of various ailments and disorders. Hence, a lot of efforts have been made to develop efficient synthetic strategies for the preparation of a variety of pyrazoles in the past several decades. However, this review describes the environmentally benign protocols for the synthesis of substituted and fused pyrazole molecules.

Keywords: Aromaticity, biological activity, eco-friendly methods, ionic liquids, pyrazoles, pyrano[2, 3-c]pyrazoles.

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Year: 2019
Page: [198 - 209]
Pages: 12
DOI: 10.2174/2213346106666191026094131

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