Background: Esophageal cancer (EC) is the sixth leading cause of cancer
death worldwide, and the overall incidence is increasing.
Objective: The aim of this study was to evaluate the association between single
nucleotide polymorphisms in IL1R2 and EC risk in the Chinese population.
Methods: Genotyping of six SNPs of IL1R2 was performed with the Agena
MassARRAY platform from 384 EC and 499 controls. The association between
polymorphisms and EC risk was assessed by performing genetics models and haplotype
Results: Overall analysis results showed that the allele C of rs11674595 (odds ratio
[OR] = 1.42, 95% confidence interval [CI]: 1.14-1.77, p = 0.002) and allele G of
rs2072472 (allele: OR = 1.35, 95% CI: 1.08-1.69, p = 0.008) were associated with an
increased EC risk. The rs11674595 and rs2072472 were found to be correlated with EC
risk under the codominant, dominant, and additive models. Stratification analysis found
that rs11674595 and rs2072472 were associated with increased EC risk in male and in
age > 55 years old subgroup. In addition, Crs11674595Grs4851527 haplotype was significantly
associated with 1.44-fold increased risk of EC (95% CI: 1.12-1.84, p = 0.004).
Conclusion: Our results reveal the significant association between SNPs (rs11674595
and rs2072472) in the IL1R2 and EC risk in the Chinese Han population. The findings
may provide meaningful reference for the prevention and treatment of EC.