Anti-Alzheimer’s Materials Isolated from Marine Bio-resources: A Review

Author(s): Anuruddhika Udayangani Rathnayake, Racheal Abuine, Yong-Jae Kim, Hee-Guk Byun*.

Journal Name: Current Alzheimer Research

Volume 16 , Issue 10 , 2019

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Abstract:

The most common type of dementia found in the elderly population is Alzheimer’s disease. The disease not only impacts the patients and their families but also the society therefore, the main focus of researchers is to search new bioactive materials for treating AD. The marine environment is a rich source of functional ingredients and to date, we can find sufficient research relating to anti- Alzheimer’s compounds isolated from marine environment. Therefore, this review focuses on the anti- Alzheimer’s material from marine bio-resources and then expounds on the anti-Alzheimer’s compounds from marine seaweed, marine animal and marine microorganisms. Moreover, because of the complexity of the disease, different hypothesizes have been elaborated and active compounds have been isolated to inhibit different stages of pathophysiological mechanisms. Sulfated polysaccharides, glycoprotein, and enzymatic hydrolysates from marine seaweeds, peptides, dietary omega-3 polyunsaturated fatty acids and skeletal polysaccharide from marine animals and secondary metabolites from marine microorganism are summarized in this review under the anti-Alzheimer’s compounds from the marine.

Keywords: Alzheimer's disease, amyloid beta, tau protein, seaweeds, neurodegeneration, bioactive compounds, dementia.

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