Synthetic Methods and Antimicrobial Perspective of Pyrazole Derivatives: An Insight

(E-pub Ahead of Print)

Author(s): Harish Kumar, Kushal Kumar Bansal, Anju Goyal*.

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

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Background: Newly emerging microbial infections and development of resistance against cutting-edge therapeutics has created deep necessity for innovative and robust medicinal agents. Small ring heterocycles, such as pyrazole and its derivatives have been acknowledged to possess myriad biological properties and presence of pyrazole in clinics like celecoxib, phenylbutazone (anti-inflammatory), CDPPB (antipsychotic), rimonabant (anti-obesity), antipyrine, difenamizole (analgesic), fipronil (broad-spectrum insecticidal), betazole (H2-receptor agonist) and fezolamide (antidepressant) drugs have proven the pharmacological perspective of pyrazole nucleus.

Objectives: The current review paper aimed at recent update made on novel methodologies adopted in synthesis of pyrazole derivatives with emphasis on antibacterial (DNA gyrase inhibition) and antifungal activities.

Method: Pyrazole is one of the major tools to be investigated in drug design and discovery. Many studies have been reported by researchers that has claimed the significant biological potential of these derivatives. However, numerous studies on pyrazoles compounds shown to exhibit potential antifungal and antibacterial activities, the focus has also been made on DNA gyrase inhibition. Additionally, the some important patents granted to this heterocyclic nucleus related to antimicrobial potential are also addressed appropriately.

Results: DNA gyrase is promising biotarget yet to be explored against a number of medicinal agents. The present work provides valuable insight into synthetic methods and antibacterials/antifungal significance of pyrazoles in general as well as new inhibitors of DNA gyrase in particular.

Conclusion: The manuscript constitutes a valuable reference which advocates candidature of pyrazoles as a potential therapeutic alternative as antibacterial and antifungal agent.

Keywords: Pyrazoles, DNA gyrase, antimicrobial, antifungal, antibacterial, patent

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2211352517666191022103831