Background: AdipoRon is the first synthetic analog of endogenous adiponectin, an adipose
tissue-derived hormone. AdipoRon possesses pharmacological properties similar to adiponectin and its
ability to bind and activate the adipoR1 and adipoR2 receptors makes it a suitable candidate for the
treatment of a multitude of disorders.
Objective: In the present review, an attempt was made to compile and discuss the efficacy of adipoRon
against various disorders.
Results: AdipoRon is a drug that acts not only in metabolic diseases but in other conditions unrelated to
energy metabolism. It is well- reported that adipoRon exhibits strong anti-obesity, anti-diabetic, anticancer,
anti-depressant, anti-ischemic, anti-hypertrophic properties and also improves conditions like
post-traumatic stress disorder, anxiety, and systemic sclerosis.
Conclusion: A lot is known about its effects in experimental systems, but the translation of this knowledge
to the clinic requires studies which, for many of the potential target conditions, have yet to be
carried out. The beneficial effects of AdipoRon in novel clinical conditions will suggest an underlying
pathophysiological role of adiponectin and its receptors in previously unsuspected settings.