Background: Natural phenolic compounds in medicinal herbs and dietary plants are
antioxidants which play therapeutic or preventive roles in different pathological situations, such as
oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade
is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks.
Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA,
and the putative mechanisms of action are described. Ethnopharmacological reports related to these
bioactivities are also reviewed.
Materials and Methods: An electronic literature search was conducted by authors up to October
2019. Original articles were selected.
Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic
pain in animal models.
Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain
management via bolstering antioxidant defenses against inflammatory insults.