The field of heterocyclic chemistry has been revolutionized using transition
metal catalysts in recent years. Various research groups have focused on the development
of general protocols to achieve better functional group compatibilities and greater levels of
molecular complexity under mild reaction conditions, using easily available starting substrates.
The methodologies used earlier for their synthesis were less approachable to organic
chemists because of their high cost, highly specified instrumentation and inconvenient
methods. For both stereoselective and regioselective synthesis of five-membered nitrogen-
containing heterocycles, cyclic reactions that are Ru-catalyzed have known to be
very efficient. These methods have many advantages as compared to alternative pathways
involved in the synthesis of heterocyclic compounds. In this review article, we concentrated
on the synthesis of nitrogen-containing five-membered heterocycles in the presence of a ruthenium catalyst.
This review mostly covers the literature published during the period from 1977-2019.
Keywords: Ruthenium, catalysis, heterocycles, nitrogen, synthesis, five-membered heterocycles.
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