Surgical Principles for the Management of Epithelial Ovarian Cancer and A Review of Seminal Theraputic Clinical Trials and Emerging Therapies
Pp. 1-45 (45)
Jamal Rahaman and Lorene M. Yoxtheimer
Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer
death in the United States and is the fifth most common cause of US cancer mortality
in women. It is estimated that 22,440 women are diagnosed with EOC and 14,080 die
from the disease in the United States each year . Using the Surveillance,
Epidemiology and End Results 1995-2007 database, stage I,II, III, and IV EOC have 5-
year survival rates that are 89%, 70%, 36%, and 17%, respectively while the 10-year
survival rates are 84%, 59%, 23%, and 8%, respectively . EOC is most commonly
diagnosed in women in their sixth and seventh decades. The median age at diagnosis is
63. Incidence is directly proportional to age and more than 70% of patients have
advanced disease at initial presentation .
In this chapter, we will explore the foundational principles of surgical management of
EOC and highlight critical adjuvant therapeutic trials (mostly Level I data) including
chemotherapy, biologic therapy, endocrine therapy, and targeted therapy. We will also
evaluate the prospects of emerging therapies including immune-modulation and
Bevacizumab, BRCA mutation, Carboplatin, Dose-Dense
Chemotherapy, Epithelial Ovarian Cancer, Endocrine Therapy, Emerging
Therapies, HIPEC, Immunotherapy, Intraperitoneal Chemotherapy, Minimally
Invasive Surgery, Maintenance Therapy, Neoadjuvant Chemotherapy, Primary
Cytoreduction, Prophylactic Salpingo-oophorectomy, Paclitaxel, PARP Inhibitor,
Staging Operation, Secondary Cytoreduction, Vaccine Therapy.
Division of Gynecologic Oncology Icahn School of Medicine at Mount Sinai, New York, USA.