Studies on X-Ray Diffraction, Thermogravimetric Stability, Antibacterial- Antifungal Activity of Fe(II), Ni(II), Cu(II) Metal Chloroquine Complexes Against Bacterial Strains and Fungal Spore

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Author(s): Mukesh Shankarrao Kadam*, Sachin Atmaram Khiste, Satish Ashruba Dake, Bhimrao Chintamanrao Khade.

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

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Abstract:

Synthesis of new coordination complexes has a demanding interest for inorganic chemists as well as researchers. A literature survey has revealed that main group elements as well as transition metals with ligand like Schiff’s base and many drug which having ability to form coordinate bond. 3d-series of metal complex with Chloroquine as a ligand was synthesized (ML2) stoichiometricaly and characterized by conductivity, melting point, UV-spectra, TGA and X-ray analysis of coordination complexes and Anti-microbial activity. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the bacterial strains such as Plasmodium falciparum, Pseudomonas aeruginosa, E. coli, Streptococcus, Bacillus, Staphylococcus aureus and Aspergillus Niger. The metal complex shows the very potential antibacterial as well as antifungal activity like commercial drug. The inorganic chemistry gives us good opportunities to use metal complexes as Pharmacological agents.

Keywords: Antimicrobial activity, Coordination complexes, Chloroquine, Conductivity, Metal Complex, Ligand

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(E-pub Ahead of Print)
DOI: 10.2174/2211352517666191021090630