Green Protocols for the Synthesis of 3,3’-spirooxindoles – 2016- mid 2019

Author(s): Ani Deepthi*, Noble V. Thomas, Vidya Sathi.

Journal Name: Current Green Chemistry

Volume 6 , Issue 3 , 2019

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Graphical Abstract:


Spirooxindoles, particularly 3,3’-spirooxindoles constitute a privileged structural scaffold owing to the intensive biological activities which they possess. Because of this over the last twenty years, a large number of methods were devised for their synthesis and some of these molecules have entered pre-clinical trials. Of late, methods for spirooxindole synthesis using green protocols have developed rapidly. Reactions based on multicomponent strategies using non-catalytic / biocatalytic pathways and those done in aqueous media have been largely employed for the synthesis of 3,3’- spirooxindoles. This review focusses on the synthesis of 3,3’-spirooxindoles via green protocols and covers the literature from 2016 onwards (2016 - mid 2019); a review on the same topic has appeared in 2016. The green methods discussed here include reactions done in aqueous media, multicomponent strategies, alternate solvents and photocatalysis.

Keywords: 3, 3'-spirooxindoles, multicomponent reactions, spiropyrans, spiropyrrolidines, catalysts, green.

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Article Details

Year: 2019
Page: [210 - 225]
Pages: 16
DOI: 10.2174/2213346106666191019144116

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