Brain Volumes of very Low Birth Weight Infants Measured by Two-dimensional Cranial Ultrasonography: A Prospective Cohort Study

Author(s): Gülsüm Kadıoğlu Şimşek*, Fuat Emre Canpolat, Mehmet Büyüktiryaki, Gözde Kanmaz Kutman, Cüneyt Tayman.

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 15 , Issue 10 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Background: Cranial ultrasonography is the main neuroimaging technique for very low birth weight infants. Low brain volume is associated with poor neurologic outcome. This study aimed to calculate brain volumes of preterm infants with two-dimensional measurements of cranial ultrasonography.

Methods: Intracranial height, anteroposterior diameter, bi-parietal diamater, ventricular height, thalamo-occipital distance and ventricular index were measured with routine cranial ultrasonographic scanning. Brain considered a spheric, ellipsoid model and estimated brain volume (EBV) was calculated by subtracting two lateral ventricular volumes from the total brain volume.

Results: One hundred and twenty-one preterm infants under a birth weight of 1500 g and 32 weeks of gestational age were included in this study. The mean gestational age of study population was 27.7 weeks, and mean birthweight was 1057 grams.

Twenty-two of 121 infants had dilated ventricle, in this group, EBV was lower than normal group (202 ± 58 cm3 vs 250 ± 53 cm3, respectively, p<0.01). Advanced resuscitation, bronchopulmonary dysplasia and late-onset sepsis were found to be independent risk factors for low brain volume in our data.

Conclusion: Estimated brain volume can be calculated by two-dimensional measurements with cranial ultrasonography.

Keywords: Cranial ultrasonography, brain volume, ventricular volume, very low birth weight, preterm newborn infant, dilated ventricle.

[1]
Maunu J, Parkkola R, Rikalainen H, Lehtonen L, Haataja L, Lapinleimu H. Brain and ventricles in very low birth weight infants at term: a comparison among head circumference, ultrasound, and magnetic resonance imaging. Pediatrics 2009; 123(2): 617-26.
[http://dx.doi.org/10.1542/peds.2007-3264] [PMID: 19171630]
[2]
Pappas A, Adams-Chapman I, Shankaran S, et al. Neurodevelopmental and behavioral outcomes in extremely premature neonates with ventriculomegaly in the absence of periventricular-intraventricular hemorrhage. JAMA Pediatr 2018; 172(1): 32-42.
[http://dx.doi.org/10.1001/jamapediatrics.2017.3545] [PMID: 29181530]
[3]
Horsch S, Bengtsson J, Nordell A, Lagercrantz H, Adén U, Blennow M. Lateral ventricular size in extremely premature infants: 3D MRI confirms 2D ultrasound measurements. Ultrasound Med Biol 2009; 35(3): 360-6.
[http://dx.doi.org/10.1016/j.ultrasmedbio.2008.09.006] [PMID: 19056162]
[4]
Keunen K, Kersbergen KJ, Groenendaal F, Isgum I, de Vries LS, Benders MJ. Brain tissue volumes in preterm infants: prematurity, perinatal risk factors and neurodevelopmental outcome: a systematic review. J Matern Fetal Neonatal Med 2012; 25(Suppl. 1): 89-100.
[http://dx.doi.org/10.3109/14767058.2012.664343] [PMID: 22348253]
[5]
Ment LR, Bada HS, Barnes P, et al. Practice parameter: neuroimaging of the neonate: report of the quality standards subcommittee of the American academy of neurology and the practice committee of the child neurology society. Neurology 2002; 58(12): 1726-38.
[http://dx.doi.org/10.1212/WNL.58.12.1726] [PMID: 12084869]
[6]
Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed 2005; 90(3): F220-4.
[7]
Liao MF, Chaou WT, Tsao LY, Nishida H, Sakanoue M. Ultrasound measurement of the ventricular size in newborn infants. Brain Dev 1986; 8(3): 262-8.
[http://dx.doi.org/10.1016/S0387-7604(86)80079-1] [PMID: 3532852]
[8]
Csutak R, Unterassinger L, Rohrmeister C, Weninger M, Vergesslich KA. Three-dimensional volume measurement of the lateral ventricles in preterm and term infants: evaluation of a standardised computer-assisted method in vivo. Pediatr Radiol 2003; 33(2): 104-9.
[9]
Papile L-A, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92(4): 529-34.
[10]
Jobe AH, Bancalari EH. Controversies about the definition of bronchopulmonary dysplasia at 50 years. Acta Paediatr 2017; 106(5): 692-3.
[11]
Levene MI. Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child 1981; 56(12): 900-4.
[http://dx.doi.org/10.1136/adc.56.12.900] [PMID: 7332336]
[12]
Brouwer MJ, de Vries LS, Groenendaal F, et al. New reference values for the neonatal cerebral ventricles. Radiology 2012; 262(1): 224-33.
[http://dx.doi.org/10.1148/radiol.11110334] [PMID: 22084208]
[13]
Davies MW, Swaminathan M, Chuang SLBF, Betheras FR. Reference ranges for the linear dimensions of the intracranial ventricles in preterm neonates. Arch Dis Child Fetal Neonatal Ed 2000; 82(3): F218-23.
[http://dx.doi.org/10.1136/fn.82.3.F218] [PMID: 10794790]
[14]
Graca AM, Cardoso KR, da Costa JM, Cowan FM. Cerebral volume at term age: comparison between preterm and term-born infants using cranial ultrasound. Early Hum Dev 2013; 89(9): 643-8.
[http://dx.doi.org/10.1016/j.earlhumdev.2013.04.012] [PMID: 23707692]
[15]
Doria V, Arichi T, Edwards DA. Magnetic resonance imaging of the preterm infant brain. Curr Pediatr Rev 2014; 10(1): 48-55.
[http://dx.doi.org/10.2174/157339631001140408120821] [PMID: 25055863]
[16]
Rademaker KJ, Uiterwaal CS, Beek FJ, et al. Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age in children born preterm. Arch Dis Child Fetal Neonatal Ed 2005; 90(6): F489-93.
[17]
Counsell SJ, Rutherford MA, Cowan FM, Edwards AD. Magnetic resonance imaging of preterm brain injury. Arch Dis Child Fetal Neonatal Ed 2003; 88(4): F269-74.
[http://dx.doi.org/10.1136/fn.88.4.F269] [PMID: 12819156]
[18]
Fox LM, Choo P, Rogerson SR, et al. The relationship between ventricular size at 1 month and outcome at 2 years in infants less than 30 weeks’ gestation. Arch Dis Child Fetal Neonatal Ed 2014; 99(3): F209-14.
[http://dx.doi.org/10.1136/archdischild-2013-304374] [PMID: 24406677]
[19]
Sondhi V, Gupta G, Gupta PK, Patnaik SK, Tshering K. Establishment of nomograms and reference ranges for intra-cranial ventricular dimensions and ventriculo-hemispheric ratio in newborns by ultrasonography. Acta Paediatr 2008; 97(6): 738-44.
[http://dx.doi.org/10.1111/j.1651-2227.2008.00765.x] [PMID: 18397357]
[20]
Perry RN, Bowman ED, Murton LJ, Roy RN, de Crespigny LC. Ventricular size in newborn infants. J Ultrasound Med 1985; 4(9): 475-7.
[http://dx.doi.org/10.7863/jum.1985.4.9.475] [PMID: 3903200]
[21]
Govaert P, de Vries LS. An atlas of neonatal brain sonography. London: Mac Keith Press 1997; p. 10.
[22]
Reeder JD, Kaude JV, Setzer ES. The occipital horn of the lateral ventricles in premature infants. An ultrasonographic study. Eur J Radiol 1983; 3(2): 148-50.
[PMID: 6873077]


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 10
Year: 2019
Page: [994 - 1000]
Pages: 7
DOI: 10.2174/1573405615666191019100114
Price: $58

Article Metrics

PDF: 13
HTML: 1
EPUB: 1
PRC: 1