Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives

Author(s): Fatemeh Malamiri, Samad Khaksar*, Rashid Badri, Elham Tahanpesar.

Journal Name: Current Organic Synthesis

Volume 16 , Issue 8 , 2019

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Graphical Abstract:


Abstract:

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media.

Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points.

Result: Various products were obtained in good to excellent yields under reaction conditions.

Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

Keywords: Fluorinated alcohols, green chemistry, triazole, multicomponent, heterocyclic, anticancer.

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VOLUME: 16
ISSUE: 8
Year: 2019
Page: [1185 - 1190]
Pages: 6
DOI: 10.2174/1570179416666191018145142
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