TRIM45 Suppresses the Development of Non-small Cell Lung Cancer

Author(s): Xiyang Peng, Yao Wen, Lagabaiyila Zha, Jian Zhuang, Li Lin, Xu Li, Yu Chen, Zhiqiang Liu, Shuangli Zhu, Jifeng Liang, Zuoqiong Zhou, Wuzhou Yuan, Yongqing Li, Yuequn Wang, Zhigang Jiang, Xiaoyang Mo, Yongqi Wan, Yan Shi, Ping Zhu, Lan Zheng*, Changfa Tang*, Xiushan Wu*, Xiongwei Fan*.

Journal Name: Current Molecular Medicine

Volume 20 , Issue 4 , 2020

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Abstract:

Background: Previously, we first identified the human tripartite motifcontaining protein 45 (TRIM45) acts as a novel transcriptional repressor in mitogenactivated protein kinase (MAPK) signaling pathway. After that, the inhibitory role of TRIM45 in the development of tumor was gradually unveiled. However, the function of TRIM45 in the tumorigenesis of lung cancer has not been characterized.

Methods and Results: In this study, we found that TRIM45 was up-regulated in earlystage human non-small-cell lung cancer (NSCLC) tissues. Overexpression of TRIM45 in lung cancer cells induces G1 arrest and promotes apoptosis, which accompanied by upregulated expression of RB, p16, p53, p27Kip1, and Caspase3 and down-regulated expression of CyclinE1 and CyclinE2. Further detection of the expression of the molecules in the MAPK signaling pathway revealed that overexpression of TRIM45 in lung cancer cells promotes phosphorylated p38 (p-p38) activation and inhibits phosphorylated ERK (p-ERK) activation. In accordance with this, p-p38 is increased while p-ERK is decreased in lung cancer tissues.

Conclusion: These findings indicate that TRIM45 plays an inhibitory role in the tumorigenesis of lung cancer. High-level expression of TRIM45 in lung cancer tissue may promote cell apoptosis by activating p38 signal and inhibit proliferation by down-regulating p-ERK, which provides a new clue for understanding the tumorigenesis of lung cancer.

Keywords: TRIM45, NSCLC, lung cancer, apoptosis, inhibitory role, MAPK pathway.

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Article Details

VOLUME: 20
ISSUE: 4
Year: 2020
Page: [299 - 306]
Pages: 8
DOI: 10.2174/1566524019666191017143833
Price: $65

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