In Vitro Evaluation of Antifungal Activities by Permeation of Ru(III) Complexes Derived from Chitosan-Schiff Base Ligand

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Author(s): T. Vadivel*, M. Dhamodaran, S. Kulathooran, M. Kavitha, K. Amirthaganesan.

Journal Name: Current Applied Polymer Science

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Background: The transition metal complexes derived from natural biopolymer which is very potent material in various research area of study.

Objective: To make an evident for the preparation of ruthenium(III) complexes from chitosan Schiff base ligand for effective application in antifungal studies.

Methods: Chemical modification was carried out through condensation reaction of chitosan with some aromatic aldehydes, which results in the formation of bidentate Schiff base ligand. The Ru(III) complexes were prepared by complexation of ruthenium metal ion with bidentate ligands. The series of Ru(III) complexes were characterized by Scanning Electron Microscope with Electron dispersive X-ray (SEM-EDX) analysis, Powder XRD. The development of biopolymer-based transition metal complexes has potential use in biological activity. The synthesized metal complexes were administered for antifungal study by disc diffusion method.

Results: The antifungal results showed that the transition metal complexes have significant antifungal activities against some important kind of fungal pathogens such as Aspergillus flavus, Aspergillus niger, Fusarium oxysporum, Penicillim chryogenum and Trigoderma veride.

Conclusion: Chitosan biopolymer has offered some peculiar features such as biodegradable, biocompatible which have favoured towards green synthesis of transition metal complexes through complexation with bidentate ligands. These metal complexes possessed good antifungal property due to its chelation effect on micro-organisms.

Keywords: Chitosan, bidentate ligands, ruthenium(III) complex, antifungal study, chitosan Schiff base ligand, fungal pathogens

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(E-pub Ahead of Print)
DOI: 10.2174/2452271603666191016130012