The predictive role for ST2 in patients with acute coronary syndromes and heart failure.

(E-pub Abstract Ahead of Print)

Author(s): Vasiliki Tsigkou*, Gerasimos Siasos*, Evanthia Bletsa, Maria- Evi Panoilia, Angeliki Papastavrou, Georgios Kokosias, Evangelos Oikonomou, Nikolaos Papageorgiou, Marina Zaromitidou, Georgios Marinos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G. Papavassiliou, Dimitris Tousoulis.

Journal Name: Current Medicinal Chemistry


Intensive research has shed light to the utilization of novel biomarkers which facilitate the diagnosis and prognosis of patients with different medical problems. One of the most important biomarkers especially in the spectrum of heart failure is soluble ST2 (sST2, soluble suppression of tumorigenicity 2), which is involved in inflammation, fibrosis and cardiac stress. In the revised 2017 ACC/AHA/HFSA “Focused Update Guidelines for the Management of Heart Failure” ST2 was given a class-IIa recommendation for the optimal risk assessment in patients with heart failure. Many studies indicate that not only baseline but also serial measurements of ST2 can accurately predict future cardiovascular events in patients with acute coronary syndromes and heart failure. Therefore, in this review we are going to discuss the studies about the prognostic significance of ST2 in patients with acute coronary syndromes, acute and chronic heart failure.

Keywords: acute coronary syndromes, biomarkers, coronary artery disease, heart failure, prognosis

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/0929867326666191016121630
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